Tirzepatide (Mounjaro)

Of course. And i am finding out that if i cheat at all it must be stopping me from losing weight I thought it night fall in my off anyway but it has not.For the first few weeks it curbed my appetite but that stopped. And i still vomit once a week. Have no choice but to up my dose but i am scared i will get more sick. Same thing happened with Ozempic but i had to stop because i was sick all the time. Talk to Dr this week. I really don’t want to up dose but this is not working, it works enough to make me sick but that is all. So disappointed. Last hope

Using it since June. Not really having any side effects (*maybe* some acid reflux?) but it’s not anything at all that impacts my quality of life or would make we want to stop taking it. My appetite suppression is great and I’m losing weight exactly as I should be. My only regret is not starting sooner!

I know this is an old post but just came to say I’m on day 3 after the shot and this is miserable lol. No energy, nausea, loose stools, shakiness, body aches. I hope it’s worth it though

my experience with tirzepatide on 11/13, i took a 2.5 mg injection of tirzepatide. i had done some research beforehand, but i wish i had researched it more thoroughly. i knew nausea and vomiting were common side effects, and i assumed i could handle it since I had dealt with severe nausea during pregnancy. i was wrong :( within just a few hours of the injection, i began experiencing intense body aches, as if I had been hit by something. i vomited the small amount of food i had eaten that day, which was only a bowl of oatmeal. From 11/13 to now (11/18), I have been unable to keep down anything, not liquids, not light foods, nothing. yesterday, 11/17, i finally decided to go to the ER. i explained everything to them, and they immediately performed extensive testing: three blood samples, a CT scan, an EKG, an X-ray, and...Read more...

I had minor nausea (mainly from empty stomach) and fatigue on the first few days after shot. Now, 14 shots in, those side effects are gone and now working to treat a bit of constipation. Water, water, water. Drink the water!

I am on week 3 of Tirzepatide, this coming Sunday will be my 4th shot. Week 1, nothing. Week 2 I started to notice that my hunger and cravings were reduced and when I would eat, my portions were smaller. After starting Week 3 this past Sunday, I have noticed more that I can go a long time without even thinking about food. It was recommended to me that if you are cutting out Soda/tea/coffee that you would get headaches. To help combat that, you need to either drink some salt water or add sodium somewhere. I started adding the Liquid IV packets to my bottles of water everyday and that has been awesome! For fatigue- Are you also taking B-12 shots? I added those to my weekly injections as well and it helps for sure. Lastly, starting this week (3), I began to notice bowel issues when I eat...Read more...

3rd day after first injection and I haven't stopped having nausea. No vomiting. But the nausea, fatigue and muscle pain has been nearly been impossible to work with. Im not sure if I can go the distance if this keeps up. Its almost overwhelming. Hopefully it calms down as the dose dissipates but im not excited about next week's shots.

My first week in Dec was good I suffered from chronic hunger I'm a gastric bypass person with more weight to lose. I'm not diabetic. I had the first bottle from (Utah) Compound pharmacy mailed to me did great little to no side effects. The hunger went away completely. First month TZ 2.5 from a compound pharmacy in pharmacy in my state instant injection site rashes very itch and blotchy. Found they use B6 in their mix. My MD said I can stay on 2.5 or move to 5 so I tried 5 and again bad injection site rashes needing treatment. Went back to 2.5 still same rashes and worse nausea and cramping. My own experiment I'm going back to the original compound pharmacy that only uses TZ with no other ingredients. It's odd because B6, B12 and glycerin are supposed to be useful in the TZ.

I haven’t had any serious side effects. Some GERD with some god awful taste and waves of queasiness mostly in the day after I do the shot. That’s it so far and 5 weeks. I’m moving up to 5mg today so we will see.

Fatigue and some nausea - this is pretty common. Some places even mix their sema or tirz with B12 to help offset this very common side effect. Eat high protein, simple foods if you can. Avoid greasy food. Drink lots of water as others have said. I didn't notice much in terms of skin, but the fatigue was noticeable for several weeks to me.

Im currently in my second week of tirzepatide and I injected in my leg this time and haven’t had any nausea side effects so far, however I do feel much more tired today and I can’t tolerate sweet drinks. I usually drink Ghost protein and lemonade drops and today I just couldn’t tolerate any sweetness and had to toss my protein shake and my water. My tastes for things are different, like I crave rye toast and bacon, tuna and mayo, and loved the sesame seeds on the rye bread so much I was picking them off the plate 😂

I'm sorry you are having these side effects. Had my 4th shot Thursday of 2.5 mg compounded Tirzepatide. No muscle or mental problems, no fatigue. Only slight nausea the first couple of days three weeks ago. However, as I mentioned to another poster, my hunger has not diminished significantly like others are reporting. I thought my face looked dry this morning and I was even using a new, not cheap, nigh-time moisturizing mask. So, it was interesting you mentioned the dry skin. I know I definitely need to drink more water.

No matter what , every single person will react different to the medication. For me I had extreme fatigue before I started tirzepatide , always felt sluggish , & the medicine actually gave me energy and I haven’t felt this good in a couple years . I started in August 2024 , SW 216 CW 171 GW 165 . I did 2.5mg for 4 weeks , and have been on 5mg this whole time . I’m loosing weight still but slowly now , and I don’t plan to move up in dose since I’m so close to my goal weight , unless I completely hit a plateau. First few weeks of medication I would get migraines the day of the shot and It was hard eating anything since I nothing seemed appealing . Those are the only side effects I recall , I haven’t had migraines since probably October ,...Read more...

I just took my 3rd shot of the 2.2mg. I've stalled at about 2 lb loss even though I've incorporated walking. Will start. 4.4 after another week. I'm hoping it makes a difference. Any thoughts? The only thing I've experienced.is heartburn. I did have pain at injection site this time around but probably because.ive been using the same area.

I am so tired of being sick! Started on tirzepatide 14 weeks ago - the usual small doses increasing every 4 weeks. No matter what I read on user sites, I cannot get my GI system settled. Nausea, sulfur burps, diarrhea, reflux, ugh. Have lost weight and was trying to hang on to lose another 10 lbs but not sure I’m going to make it. I’m using any recommendations I have read but cannot feel “good”. Is it just me or are others walking around half sick?

I've been on a similar journey and can relate to some of what you're describing, especially the fatigue and adjustment period. I get my Trizepatide from Amazing Meds, and it's been a game-changer for me. I also had some of those side effects early on, but they've definitely subsided as my body has gotten used to the medication. It's great that you're already feeling better in some ways, and I hope things continue to improve for you!

Well, I had almost every single side effect one could possibly have. I had really bad acid reflux and nausea. I vomited probably three times the day after one of the shots. I’m on week 18 now and I’m titrating up to 12.5 in another week. I’ve lost 17 pounds which is slow I know, but I’m only trying to lose 20 more. I’m glad I stayed with it because nothing else was working. I could starve myself and not lose weight, I could work out till I was gonna fall over and it didn’t help. The exhaustion was almost unbearable but now I feel really good. I don’t know why it took me four months to get here but I’m here. Bonine works very well for nausea.

I'm at the end of my 2nd week, getting ready to take my 3rd shot tonight. 2.5mg. I'm kind of amazed, but will wait to see. I was freaked out at first because I'm more hungry, find that I'm eating regularly, and have lost 9lbs in 2 weeks. I have PCOS, and so, I've always had a balanced, high fiber/mediterranean diet and no matter how much I would work out or fast, there was not significant change. Previously I could not lose weight with intermittent fasting, and I wouldn't have much of an appetite after eating breakfast. I can only assume that metabolic shifts are working and my body is able to burn fat and intake my BMR caloric requirements without immediately storing them as fat. But it is still early. I haven't felt any different yet except for a bit less brain fog which is amazing. Physically I feel...Read more...

I've been taking Terzepatide  for 1 week now. First nights of sleep were very little sleep/ no Rem sleep. Once that pit in my stomach disappeared,  the sleep became a little better with help of Magnesium  Glycanate or Melatonin. Appetite is suppressed and has allowed me to say no to fried foods, fast food etc . I've lost 4 lbs this first week, but then I'm over 200 lbs. During the day if I hadn't get adequate  sleep I feel sluggish yet awake. I'm going to proceed with Tshot for a while to see how well it works for me. Active with job but no exercising.

Bizarre experience on tirzepatide Hi all - others have advised me to post here. I’d like to share this experience to see if any of you might have had the same thing and/or can explain what’s going on physiologically. I started taking tirzepatide (2.5mg) to deal with relentless sugar cravings that wouldn’t go no matter what. When I say relentless, I really mean relentless. I’m not diabetic and my blood sugar is, inexplicably, in the normal range. I’m 5’3 and my starting weight was 50kg (110lbs). I heavy weight train 3 times a week plus 3 cardio sessions a week, and get a very high step count daily. My intention wasn’t to lose weight - it was to shut down or at least limit the sugar noise. I don’t normally crave normal, savoury food. Pre-tirz, I’d eat 1600-1650 kcal a day, with around 120g protein. I started on 2.5mg, cravings...Read more...

1st Week Result – Tirzepatide (2.5mg) Hi everyone! Just wanted to share my **Week 1 experience** on Tirzepatide (2.5mg). I know a lot of us are curious about how the first dose goes, so here’s how mine turned out: 💉 **Dose:** 2.5mg 📅 **Day 1 to Day 3:** * I felt **very full**, even with small meals. * Food didn’t appeal to me much — I had that “quiet food noise” everyone talks about. * Energy was low, but manageable. 📅 **Day 4 to Day 7:** * **Food noise came back.** I was still thinking about food, though cravings were more manageable. * Appetite wasn’t as strong as before, but I did catch myself snacking. * I had **on-and-off migraines**, especially on Days 2 and 4. * Felt **really tired and weak** — like I had no drive to do anything. ⚖️ **Weight Loss:** I still managed to lose **2kg...Read more...

Add a vote for miracle medicine. 20 yrs on levothyroxine and multiple 30-40# weight gains that I didn’t always lose all after gaining. Increasing inflammation each year from increasing weight gain/TSH swings/life. Enter Zepbound… 15lb loss in first 2-3 months and was able to break up with my rheumatologist. Down 35 lbs at 8 months, but more important was the almost disappearance of inflammation in both small and large joints around month 3. My body is literally not gummed-up anymore. I had mild stomach cramps with the very first dose, a little lethargy on day 2 after shots for the first month, and a mild red/itchy site injection 2 days after the 5mg injections, but that’s the end of my side effects. They were very worth this level of feeling better. I’m due for a TSH retest, but so far the Zep & weight loss hasn’t made my TSH swing...Read more...

💯 recommend it! I’m on it and i love it. For reference, i am 5’4” and weigh 140. It helped me lose the ridiculous 25lb hashimotos gave me in less than one year. AndI tried for over two years unsuccessfully to lose the weight and it would not budge. I will stay on it for the amazing benefit it has for inflammation!

I am one of the people in this group who has yet to receive a formal Hashimotos diagnosis but have all the symptoms. I started taking Zepbound (tirzepatide) in August. I’m currently on my 3rd month of 5mg. I started with 3 months of 2.5mg. I’ve lost 50lbs so far. I have had no major side effects at all. If you drink enough water and eat enough protein it works amazing! Inflammation is under control, fatigue has improved greatly, brain fog gone, anxiety way less, stopped taking a lot of the meds I was on as I no longer need them. This stuff is honestly a miracle!

It is literally a miracle for me. I woke up feeling like a new person the day after I took it! The joint pain and stiffness disappeared, and the inflammation has subsided. Plus, I actually have energy now. I will take it for the rest of my life.

Stay on a low dose and you'll avoid the bad side effects. I have Hashimotos and lost 73 pounds on 2.5mg of Tirzepatide.

\+1 vote for miracle medicine. Been on tirz for 6 months, down 40lbs, A1c down from 5.9 to 5.2, and unpleasant side effects have been few and far between. I experienced some minor nausea, heartburn, and dizziness at the beginning, but only lasted a day or two. Side effects might rear their head again when titrating up, but only the first dose of a higher dose, for me at least. Once I got up higher in doses, the side effects basically became null. I am currently on 15mg, and I do not experience side effects anymore. Well, outside of the wanted effects of appetite control, satiety, inflammation reduction, and food noise control. I get lots of those, and sometimes mild constipation, but next to zero negative effects at this point. The side effects at the beginning were never enough to deter me from my overall goals. Mild at their worst....Read more...

Sooooo zepbound, yes, mounjoro no. Pre hash diag, I felt like shit at 195-200 lbs. got up to 228 before diag and 243 in march when numbers came back “controlled”. So 3/17/25: 243 01/28/26: 181 I feel better than I have since 2010 and at the same time weight I was at 21 with a little more muscle. Miracle drug, no. But does make the food cravings stop.

I’m on it currently, and so far it’s been amazing. I’ve dropped probably around 10 pounds in almost 2 months. I no longer have crazy food noise. I don’t crave sugar and soda and sweets. My joint pain and general inflammation is down. My insulin is much lower(I had super high insulin before I started). I’ve been able to make healthier food choices because my brain isn’t screaming at me to only eat sweets. The only side effects I’ve noticed is some constipation, and sometimes I get nauseous(though the nausea might be related more to my migraines, so take that with a grain of salt). And now soda and sweets don’t taste as good, but for me that’s a good thing lol

I started it 2 weeks ago and so far miracle drug! I'm down 6 pounds and only a little mild nausea as a side effect. But otherwise it's the easiest time I've ever had losing weight.

It’s been a miracle for me as well! My hashimotos is well controlled but ever since I hit 35 I cannot lose or even maintain weight. It’s been horrible. I was very nervous to start Mounjaro bc I have thyroid nodules, but after trying hard for 2 years to get the weight off I finally decided to. It has been miraculous. I feel better than I have in years, including reduced inflammation. I was really worried about side effects but they’ve been minimal. Some slight nausea when I would increase my dose and hair loss, which is to be expected so I need to increase my protein. I’ve lost 60 lbs in 6 months without trying. I’m now starting to work out again and can actually do it without ever single bone and joint hurting. I can’t say enough good things

It's been amazing. Honestly. Such a game changer. Edit to add: inflammation... I noticed an almost immediate improvement

Same as the others. Tirzepatide compound (with B3 added) from GoodLife meds. I struggled with being overweight, fatigue, swelling, lethargy, apathy, and the resulting mental health issues for 6 years. I couldn't exercise because my PEM was so severe. Every part of my life was negatively affected by these struggles. Since starting TZ in October, I have lost 30 lbs. I am running again. I have energy to play with my kids at night. I have reduced food noise to a manageable volume. I'm taking better care of myself and my home. It's not just about the weight loss. This is a drug I will happily stay on for life.

I have zero side effects other than occasional dehydration and constipation. Feel incredible on it.

It's helped me lose 15-20 lbs in 4 months without any major lifestyle changes (I was exercising the same before and what I'm eating hasn't really changed). I've never been able to lose weight without a crazy diet before. It's not been a total "miracle" for me but it does work as advertised. As a note, I ended up getting appendicitis which has some literature out linking it to these drugs, so caveat emptor.

My cravings were gone the next day. I lost a dress size each month for 5 months and met my goals. With Tirzepatide I have kept it off for more than a year now.

I started compound tirzepatide (2.5) a few weeks ago and wondered this myself. I have a corporate job and flexibility to work from home two days a week, but I'm required to be in an office for the remainder. I drink a lot of water, keep my protein up and exercise nearly every day. I think this has kept a lot of the severe symptoms away, but I did have some mild nausea and fatigue especially the first few days following the shot. I am lucky enough to be able to schedule my time in office around those days where I feel worse, but it wouldn't keep me from going in the office if I had to.

I just came back to tirzeputide after ozempic failed to give me results. The only side effects my first go round was constipation. I came back in at 7.5 where I left off and the second day I had severe diarrhea, nausea and sulfur burps. Fortunately it was a Sunday but I was in a long car ride and it was hell. Lasted all night and I had to call in today. I’m feeling better but I’m so scared to ever take a shot again. Diarrhea is so much worse than constipation. At least you can go to work with the latter.

I don't have a ton of experience (2 shots in), but I only felt a little nauseous the day after my shot. Not enough to call in sick, but enough to make me less productive I think. Second shot was similar, nausea the day after. I'm thinking of doing my shot on Thursdays instead of Sundays going forward. My Fridays typically have less meetings, so easier to power through at my desk than in front of other people.

In the beginning, nausea and constipation. My husband did not have any nausea. Now I have to be careful on how much I eat in one sitting. I tend to get acid reflux rather easily, as well as feel uncomfortably full. I'm on .75.

I am 2 shots in and I have had insomnia every night starting with the first shot. I have never had insomnia before in my life. It’s been 11 nights and I really hope this is temporary! No other side effects.

I’m only on my second shot, but I’m definitely burping a lot, and getting more reflux and resultant stomach pain at night, once I’ve been asleep like 5 hours. Alcohol makes the night reflux almost unbearable, so that’s no longer a part of my life.

I’m not having any awful side effects. I wonder why some people get them and others don’t. I can say I have increased energy and focus to get through the day. I am so much more patient with my family. I fall asleep fast and stay asleep. Every once in a while, I feel a deep vibration/maybe a little coolness inside. I’m wondering if that’s my amped up metabolism. I will be getting my third shot of 2.5 tomorrow. I get mine after breakfast on Mondays and feel great throughout the day. I eat pretty clean. Maybe it has to do with what we are eating?

Felt a little nausea, but not enough to make me not be able to work. Overall, I've had a good experience and can't say it's impacted my work negatively. If anything, I now have a bit more energy and I'm feeling less bloated which makes me feel better in general.

I just started 2.5 this week and I’m absolutely suffering. Haven’t ate in days. Exhausted. Abdominal pain like even to the touch, constant nausea even with zofran. Gas and indigestion. Burping a ton with reflex coming up the whole time. I regret it

I had one episode of constipation and queasiness when I began the 5mg level. It came and went but lasted a few days. It may have been unrelated but that's all so far.

I’m in month 4 and had no results for first two. Dose has gradually been increased to 8.5mg and I’m finally seeing results. Unfortunately I’m also finally having side effects, the worst of which is severe diarrhea. Oddly enough it’s around day 4 after the injection, and so far has only been for a day.

I have restarted tirzepatide this past week after not getting any results with semaglutide. I had great results previously with Monjauro so I’m pleased to be back on it. However just 3 days after my shot, I don’t know if it’s the decrease in calories or side effect from the shot, but dang I’m tired in the afternoon/early evening. I don’t have any stomach issues. I don’t remember having this tiredness previously. I drink a lot of water and eat protein and a balanced diet every meal. Also I’m 68 years old, female and have 30 lbs to lose. Thanks for your input.

I’ve been on Tirz for eighteen months. I started at 2.5 mg, moved to 5 mg, & currently trying 7.5 mg. The last two shots of 7.5 mg have been spread out over a week. So, I’ll take 3.5 on a Friday night & the rest on the following Tuesday. With both shots (in arm), I’ve got deathly ill with vomiting & non-stop diarrhea. I cannot take Semiglutide. Any suggestions? I do not want to regain the 50 lbs I’ve lost.

I throw up a little morning after, brushing my tongue triggers it . Now that I know that I dont brush my tongue day after lol. I am peri and have graves so im usually hot all the effin time but since starting 7.5 i feel cold. I have mild headache.

I have on and off massive diarrhea 3 days after my shot. I think I finally figured out why .... Milk. In the days of my shot if u don't drink milk I go with it any problems. If I drink milk I'm sick all day on the 3rd day. Happened at 2.5 mg and this week at 12.5 mg. I'm starting month 5 and just figuring this out

I started Tirzapatide 4 days ago, ate a large meal at day 3 and suffered severe constipation and stomach cramps.... it was a long night and am just recovering. Has anyone else experienced this sort of thing? I'm basically terrified to eat anything now!!

I’m 3rd shot in of 7.5 and am having diarrhea for past week. Haven’t eaten very much so I think it’s just the shot, not a hundred percent sure

Can I ask why you came off after one month? I didn’t stay on it long either. I had nausea every day and I was freezing cold and dying of thirst even though I was pounding water. Also my heart rate was up a lot from it

I was only on tirzepatide for a month, and I think it also contains B12. At first, I felt fine, but after my last dose four days ago, everything changed. I ended up in the hospital with hypoglycemia, high blood pressure, strong heart palpitations, and extreme dry mouth. I decided to stop the medication because the nausea, dizziness, and fatigue became unbearable. Now I can barely eat — just saltines or Greek yogurt help a little. Anything else makes me feel worse. I’m cold all the time, shaky, and my anxiety is intense. I’m on Zofran and anxiety meds, but they barely help. I’ve been praying for this to leave my body. Has anyone else gone through this? How long did it take to feel normal again? I’m trying so hard every day, but I’m scared and exhausted.

I am glad I found this , I am three weeks off and I felt fine for weeks 1 and 2 , but half way through week 3 started getting lightheaded and little dizzy. I been on triz for a year I foolishly went up each month until December. Had terrible side effects but I thought a sinus issue i developed after covid. I found reddit groups that made realize hey dummy your injection yourself with a medication. Initial I started through ro company and they recommended going up each month once I realized what was going on i followedup with pcp. We decided to slowly go down each month , I ended up jumping down to 5mg after the second month I was at 15 went 12.5 then 5. My side effects improved still there but manageable. I have been in maintenance On 2.5 since March every two weeks...Read more...

I had terrible side effects including gastroparesis.  biggest regret of my life was taking this. I was on the lowest dose too and all seemed fine! it came out of nowhere!

Tirz gave me neuropathy in my legs and feet! Still experiencing symptoms after 3 weeks off the injection.

I was on tirzepatide for 2 months and 2 weeks. I started on a low dosage 2.5 to treat my sleep apnea. I noticed I was having daily headaches but never thought it was from the medicine. Then my doc upped my dose to 5mg and after my fourth week I woke up the next morning feeling anxious. I’ve never had any anxiety in my life but that day I had I think was panic attach. Went to urgent care which they ignored my symptoms. Two days later my anxiety got so bad I went to the ER where they gave me Ativan. Those days leading up to er I found myself In constant worry but I couldn’t explain why. I was better after that however had diarrhea a week later and some effects of anxiety. Today is day 37 of not taking the med and I started having some...Read more...

This is crazy! I’ve went on trizepeptide for 6 weeks. I felt awful usually dizzy/headaches. I got off over three weeks ago and I still feel it!!! How long did it last for? I feel like I’m going crazy

I’ve been off tirz for 3 1/2 weeks now. Anxiety is at all time high, my periods have been normal but spotting in between periods. Ready for this to all go away. I’ve talked to my NP and my GYN. They said this happens on these shots. My hormones were normal prior to starting this shot, however I couldn’t lose the 10lbs I needed to, so I tried this and yes it did work, but, I can’t deal with this. I’m 41, haven’t been on BC since I was 19, I’ve always been very regular, normal, no spotting in between periods. I should’ve done better research myself before starting this. Had I known, I wouldn’t have taken it. 

I quit tirzep (2.5mg) 7 weeks ago and am still nauseas daily, extremely full all day long, and occasional vomit. GI did an endoscopy and didn’t find much, we are doing a Gastric emptying scan next month Has anyone experienced persistent nausea since quitting? Was only on the medicine for 3.5 months and was extremely sensitive to it, which is why I had to quit. My side effects mirror exactly how I felt on the shot, maybe worse. Wondering if anyone went through anything similar and what the timeline for recovery looked like for you.

I’m glad I found this conversation I have been freaking out since 1/19/26 I wich was my 3 month on this medication that even I fell into 60”s outta nowhere it scared me I could not get it up…. I ended up taking 3 trips to hospital and 1 ambulance call in that week smh it was scary them basically laughed at me n said just eat I was like I am this is not normal i should not have to eat every hour to keep up blood sugar I was even dipping low in my sleep after week or two I stop dipping over night in my sleep thank God I had twin health from My job and they send dexcom sensor to help weight lost so that’s how I found out I was 60-70 lows … after 2 weeks got a lil better I still experience dips maybe...Read more...

No side effects in a year and half and over 100lbs lost. Drink lots water and get your veggies.

I micro dose 1.75mg every 5-7 days, I’m 5’2, went from 172lbs to 136lbs in 9 months. I get some fatigue on injection day and the day after. I had mild constipation the first 2-3 months but started taking fiber twice a week(I stopped this 3 months ago). I have family and friends that dosed at the recommended amounts of 2.5, 5, 7.5, 10, 12.5, 15. They have been sick to no end, missed work, specially events, they are miserable etc. have they lost weight? Yes…… I would micro dose, side effects are no joke.

I had fatigue in the beginning (about 6 weeks to adjust) but Tirz has been a lifesaver.

Constipation/bloating. Every dose increase the first two weeks are the worst for this for me but without maintaining a routine and supplements this would be a constant struggle for me, that took time to adjust and fine tune. In the beginning I think fatigue a bit, and I’ve been nauseous since I was a child but I never notice it being any worse - if anything less. Started July 27th at 2.5 for 5 weeks, 3.75 for 5 weeks, on second week of 5 - lost 36 lbs so far.

Yes! I'm having minimal side effects when starting or changing dose. Nausea, loss of appetite, and fatigue for one day. After that I'm fine. I'm going to lower my dose to try and see if I can find a sweet spot. I've only done three shots, about to do my 4th. check out r/tirzepatidecompound . It's very active and helpful. One of the best glp1 related groups.

I started off at .22mg because I'm super sensitive and knew I'd respond. I did! Within an hour I felt the effects and suddenly, the meal I'd eaten 2 hours previously had me feeling full. (It was weird because I didn't feel full before the pin.) I stayed at that dose for 3 weeks because I was still feeling a bit of nausea for the first 2 weeks, though Nauzene (OTC) helped. I slowly titrated over 3 months until I was at 2.2mg and that was just too much for my system, so I backed off. I had already lost 30# and was thrilled with the weight-loss, but not the muscle aches and \*extreme\* fatigue so I titrated down until now I'm off of it.

I’m on week 7. Have had a small amount of nausea with some injection sites (I know it shouldn’t matter but it seems to for me). I deal with a lot of headaches that start 24 hours after an injection - can’t seem to figure out how to avoid them. Really hoping it gets better soon (I’m very hydrated and monitoring my blood sugar). Highly recommend r/tirzepatidecompound for lots of experiences and advice!

I’ve used consistently since the first of March this year. EVRYONES different. That said- I have the weird ones …. lol 😂 just prolonged fatigue when I started until my body adjusted and I get this weird burning sensation in my mouth. That also happened when I took Wegovy so I think it’s just something my body is weird about. It comes and goes. Kinda feels like I always have mint gum that’s been in my mouth without the mint flavor if that makes sense.

I use a a small dose of tirzepatide and I’ve had minimal side effects that have decreased with time. When I first started, I would get small amounts of nausea, major fatigue and some acid reflux the day or two after the shot, but would be fine the rest of the week. Now I get some acid reflux, but that’s about it. That being said, when I went up to high I did get sick to my stomach, but that was my cue to use a lower dose. lol

No sides with Tirz. I split my 3.5mg dose into daily injections. I switched back from Reta. Even at low dose I felt like I was vibrating and my skin was sensitive. Also I had quite an appetite with Reta Appetite suppression and inflammation reduction with Tirz is the real deal. Took my body 1 month to kick in. Been on 3 months and lost 15 pounds with not a lot of weight to lose.

The only side I got was nausea when I started and did it all on one dose a week. Split it up to 2x a week and have no issue.

Started TZ last November. Never went higher than 5mg but I also stack with Cagri. Lost approximately 40ish pounds. Recently switched to Reta. No side effects from TZ...just felt like switching things up since Reta is supposed to be the superior of the GLP1s

For me, from the jump day 1 I had the most severe insomnia I have ever experienced in my life. Only 2 hours of sleep at night for two weeks, two doses is only at 2.5 mg each. I had to take a week off. Appetite suppression is real, but so is the sleep suppression. This experience did lead to me to finally quit drinking coffee, which has been part of my morning routine essentials for years to stay awake. I’ve been trying to quit, but failed. Tirzep has definitely beat out caffeine in coffee in keeping me awake. LOL

10th week of taking tirzepatide. I absolutely have drained energy. I felt fatigue and laziness since I take tirz. Although I also add NAD+ in my pep dose, I still have down energy and almost always so tired everyday. I lose weight from 65kg down to 57kg. 8kg for 10 weeks is not bad at all. But this tiredness, i hope it’ll go. Help me how?

I’ve lost 29lbs since 1/4/24, since then I’ve been able to go from 3 blood pressure pills down to 1 per day. Reduced thyroid meds from 5/week done to 4/week. Can’t wait to get my cholesterol levels checked soon hoping I can get off statins i was addicted to candy and have cabinets full of it. I haven’t had one piece since 1/4 and it’s still in the cabinets with no desire at all. More energy and haven’t felt this great in years. I’m 66yrs old. Forgot to mention I am shedding more hair than ever which is a bummer but I’m trying to eat more calories

I agree with a lot of this— whether it is literally the medication or just the overall feeling like you have a plan, a solution, and are on your way to your goals, that spark of hope can be empowering. I am 3.5 weeks in and feel more energy and desire to move more and plan fun things in the future. There has been news about it decreasing addictive behavior in general as people also drink less when on it, that also could be the health focused thinking rather than an actual solution to those that truly have an alcohol problem. But nonetheless if it helps curb unhealthy things it is a net win. I am always cold.

Been on Tirz/move from Zepbound for 7 weeks and down 16 pounds (last week moved to 5mg). My blood pressure is down 20 points and hoping to go off the BP medication. Will be talking to my Dr. end of April. I am taking one pill e/o day.

Bad My memory/ concentration is for $h1t. I can be nauseous for the first few days. I’ve had some colon pain. Good Weight loss Sense of well being Way less to no food noise I have spinal issues and they are better. The strange one is way less inflammation. In particular, my hands used to have mild arthritis but it’s all but gone.

I’m only on dose #2 but am noticing I get a tad nauseous the first few days even on 2.5 ☹️. On the positive side my inflammation is definitely reduced. I had recently been feeling my first real arthritis flair in my left hip and right hand. Significant reduction. It could also be linked to the fact that I almost completely stopped drinking. Wasn’t drinking much before but I did have about 2 a week before.

I took my first dose on Saturday 3/30 at noon, was a bit tired Sunday, but then full of energy the next three full days! I was motivated to spring clean and be active with my kids. And I've been craving fresh vegetables. I was able to keep my calories around 1900 and still lost 5 pounds! I did the second dose last Friday evening and was exhausted all the next day. I'm sick now, so the energy isn't a factor, but I'm hopeful that week 3 would be more like week 1. Does anyone else get energized like this?

(27) to (30) Over the span of two-three years (and my 2nd pregnancy!) I’ve lost 165 pounds. I wanted to show my kids that we CAN do hard things. I weigh all my food and stick to 1500 calories daily. I used the minimum dose of Tirzepatide for a few months, but unfortunately I had severe side effects, some of which I’m still dealing with. I am thankful that it helped me get my mindset right and got me started on my journey. I have learned to love weight lifting and am closing in on my goal.

(27) to (29) Trying this again because my first post got removed. Over the span of two years (and my 2nd pregnancy!) I lost 135 pounds. I wanted to show my kids that we CAN do hard things. I weigh all my food and stick to 1600 calories daily. I used the minimum dose of Tirzepatide for a few months, but unfortunately I had severe side effects, some of which I’m still dealing with. I am thankful that it helped me get my mindset right and got me started on my journey.

I started at 1.25 and am prone to migraines and stomach issues. I drink electrolytes, water, and up my protein the day before and the day of shot day. Fatty/greasy foods will make you sick. I also take iron and D3/K2. I have had no side effects at all.

5’5 starting weight was 152lbs. I started with 0.25mg because I was terrified of side effects and am usually highly sensitive to meds. Nothing negative noted for me, just had a very small amount of appetite suppression. The following week I upped to 0.5mg, and slowly increased by 0.25mg intervals depending on how I felt each week. I have never had negative side effects and am so glad I started low and have increased slowly.

I started at .25 and have never had side effects until I got to 1.5. I do have a higher heart rate and lower HRV no matter how much I take. I'll be going back down next week.

I’m 5’4, 148lb, and started about few days ago at .75mg. I was prescribed 1.25 but got scared of side effects so went lower. I took a preemptive anti-nausea pill right away. I haven’t had any problems at all. Mild food noise reduction and hunger that seems to hit when it makes sense I should be hungry.

I am 5'2 145 lbs and I started at 0.6mg because I was concerned about side effects and my starting dose was supposed to 1.25mg. I started Friday 13th and was fine on day of shot, didn't sleep well that night the next day I was extremely tired - more than I would be on one night of poor sleep, I was pretty tired on the following day so I was glad I did this over the weekend. The following Friday I took 0.6mg again, was slept fine but was still pretty wiped on Saturday but fine on Sunday

I took 2.5 mg of tirzepatide for about six weeks and then stopped because I have a competition coming up. I’m a cyclist, and my first race of the year is in four weeks. During the time I was taking it, I had almost no appetite at all. At the same time, my resting heart rate went up by 12 beats, my heart rate during exercise was correspondingly higher, and my HRV, which is normally around 60 to 70, dropped to 25. Training also became difficult. Interestingly, I kept taking a microdose of 0.25 mg per week, and I didn’t notice any negative effects from that. All my values improved again, and training was going well. Last week I had the idea to increase it to 0.5 mg, and it feels as if I’m back on a normal dose again. My appetite is clearly suppressed, my stool also becomes much...Read more...

Went from .25 to .5 recently. Very very small amount of nausea on 2nd day after shot that didnt last long.

Last night, on my first shot, I screwed up and did 16 units, or 2mg😵‍💫😵 , which is a normal starting dose. I react/over react to everything so I was planning on doing .5. (Read the bottle wrong thought the dose was 1/2 of the 2mg). I’m 47 perimenopausal, 5 ft tall and 150. Got a little nauseous last night, haven’t had my usual bm yet, and I’m really regular so that’s concerning. Because it builds up in your system, I am going to reduce the dose next week. Because I’m still scared.

Similiar to you, 43yo female, perimenopause, I was a BMI \~27 (165 at 5'6"), looking to drop 15-20 lbs. I am very sensitive to meds usually, so I started at 1mg. I had no side effects at all. Shot 2 I bumped up to 1.25mg, again no side effects at all. Shot 3 I bumped up to 1.5mg - no side effects, but it was only yesterday. I definitely notice a lack of hunger and appetite, especially around snacking or desserts, doesn't even cross my mind anymore. I am still able to eat meals, usually 75-90% of a normal portion. However, I no longer eat the additional bread or salad that I usually would make for my husband. I drink electrolytes, water, and up my protein. I don't typically like fatty or greasy fast food, but I do avoid them around shot day. I take a good quality multivitamin, vitamin...Read more...

i started at .25 for a few weeks and felt nothing. no side effects but also no change in appetite or food noise. stopped for a month (d/t some life events), gained 5 lbs and started back at .5. First shot my only side effect was insomnia for 2 of the nights, no appetite changes. Second shot was monday and i’ve had much better appetite suppression, feeling very full after a few bites etc. no insomnia but some legit nausea and constipation. definitely still have to pay attention to food choices. i will likely stay on this dose as long as i can because it seems manageable.

I started at 0.25 and the only real side effect for me was that it was too low of a dose and I got really hypoglycemic to the point where I was ravenous constantly. Upped dose to 0.5 and much better.

1st Week Result – Tirzepatide (2.5mg) Hi everyone! Just wanted to share my **Week 1 experience** on Tirzepatide (2.5mg). I know a lot of us are curious about how the first dose goes, so here’s how mine turned out: 💉 **Dose:** 2.5mg 📅 **Day 1 to Day 3:** * I felt **very full**, even with small meals. * Food didn’t appeal to me much — I had that “quiet food noise” everyone talks about. * Energy was low, but manageable. 📅 **Day 4 to Day 7:** * **Food noise came back.** I was still thinking about food, though cravings were more manageable. * Appetite wasn’t as strong as before, but I did catch myself snacking. * I had **on-and-off migraines**, especially on Days 2 and 4. * Felt **really tired and weak** — like I had no drive to do anything. ⚖️ **Weight Loss:** I still managed to lose **2kg...Read more...

I lost 9 pounds by the time I took my 3rd dose. But the scale went back up by 2lbs the following week. Now I am still at that same weight (7lbs down) and just took my 5th dose. Here’s what I’m noticing. The medicine works. I don’t crave foods, I take time to think of what I want to eat. I am able to hit my protein goals. I am able to workout how I want (couldn’t on sema) and I know I’m in a calorie deficit. I know the medication is working regardless of more weight dropping. I do think I had a lot of inflammation because I had recently had surgery and had gained water weight. I have not changed my dosage at all. I’m still at .25. Bottom line, how do you feel on it?

1 lb first week - no tracking calories 2 lbs second week -starting tracking 3 lbs a week for the next 2 weeks - starting eating 500 under my TDEE Then it leveled back off to 1-2 lbs a week and has averaged that for the following 3 months. Today I hit 35 lbs down. 30 more to go. I have stayed below the standard dosing schedule. 17 weeks I am at 7.5 mg and use split-dosing. I track every every single thing I put in my mouth, and eat a pretty clean diet. I JUST started getting exercise 2 weeks ago. It's a marathon. Do not be disappointed. The weight WILL come off. The first month for me was DRASTICALLY different than it is now as my body adjusted to this new med, new foods, new caloric intake, new macro levels. So so much adjustment. Focus on new life...Read more...

I’m 61 years old.  I started Tirz back in April when I was still 60.   I am currently on 11 mg.  I have lost 74 pounds.   And other than taking MiraLAX of a morning to stay ahead of constipation I’ve had no side effects.  

I started on a Friday just in case, and the first day after my first dose, I did notice some fatigue and mild body aches. I’m 4 weeks in now, and the only side effects I feel are mild heartburn for a couple days after each shot.

I felt tired and achy the first two days after my first shot. The subsequent shots have been much more manageable. Main symptoms are constipation and dry mouth, both of which are very manageable.  I don't think you need to plan to take a week off. I take mine Friday morning, so if I don't feel great at least it's on a weekend. 

My symptoms started at 24 hours after injection and lasted a day. For me, it was a little bit of nausea and diarrhea. I now go back and forth between diarrhea and constipation. Every body is different. I’d suggest having something to combat those and nausea. I got Zofran sent with my tirz, and I keep Pepto and magnesium on hand

I did not get sick at all. I had zero side effects. I’m now 2.5 months in at 12.5 dose and still - nothing. Just weight loss. I titrated up by doubling every five days (nurse supervised), hung out at 10 for a bit, then went up to 12.5. I changed my diet radically before I took that first dose (1200 calories or less, no red meat, no overprocessed foods, no junk, no high salt, low carb, no sugar, lots of water and fiber). I made sure not to overeat and made sure my macros were balanced so I wouldn’t invite side effects. The worst I’ve experienced is a feeling of uncomfortable fullness.

I just do my first shot yesterday shot itself zero when I say zero zero pain, when I ate I did get fuller idk if it was a placebo effect but I got fuller and lasted the rest of the night…excited to see how the rest of week goes

I had only one symptom. No hunger at all. I need to remember that is time to eat or drink water Now I am in my second week, two dosis of 2.5mg.

I was supposed toto start on 1.25mg but I ended up doing half that. I’m on week 3 I’m glad I chose to half it. The day after the shot I’m really tired, I want to see how it is after 4th shot before I increase

I did something similar but went with how I felt, not a plan. .5mg 3 weeks, .1mg 3 weeks, then 1.5mg for 7 weeks (felt perfect until I hit a plateau), 1.8mg for 3 weeks but I should’ve just gone to 2mg. I’ve been on 2mg for 6 weeks. I lost 12 lbs in 3 months (1 lb/week). Now losing about 1-2 lbs a month and kind of maintaining.

I did .5 for 2 weeks .75 for 2 weeks still didn’t feel much on those doses and just upped my dose to 1.25. I was cautious too but really had no side effects and still had the food noise.

FWIW I titrated up from .5 on my own (i used lavender health who did not give me any advice on this). Can't say I did a steady plan, I just sort of went gradually and increased probably every other week but it wasn't that intentional (hadnt seen the 4 week thing but now I may do that). My increments were much smaller than what you have above. Something like .5, .75, 1, 1.2. I'm currently at 1.2 and have lost 6 lbs in 6 weeks which for me (SW: 137) is very ideal. Gradual so I can be sure I'm not losing muscle or struggling to eat. I've had no side effects at any point.

I did 0.5 for 4 weeks and now am starting week 2 of 0.7. Like someone else said, it’s generally recommended to stay on the same dose for 4 weeks so it builds in your system before deciding to titrate up (Glapp is an awesome app! I love the way it shows how much medicine is in my body and what phase I’m in for the cycle of the meds, so definitely download that). I started at 174 and today am at 164, so 10lbs in six weeks. No plans to titrate up and if anything I might actually bump down to 0.6 next week lol

I had minor nausea (mainly from empty stomach) and fatigue on the first few days after shot. Now, 14 shots in, those side effects are gone and now working to treat a bit of constipation. Water, water, water. Drink the water!

I am on week 3 of Tirzepatide, this coming Sunday will be my 4th shot. Week 1, nothing. Week 2 I started to notice that my hunger and cravings were reduced and when I would eat, my portions were smaller. After starting Week 3 this past Sunday, I have noticed more that I can go a long time without even thinking about food. It was recommended to me that if you are cutting out Soda/tea/coffee that you would get headaches. To help combat that, you need to either drink some salt water or add sodium somewhere. I started adding the Liquid IV packets to my bottles of water everyday and that has been awesome! For fatigue- Are you also taking B-12 shots? I added those to my weekly injections as well and it helps for sure. Lastly, starting this week (3), I began to notice bowel issues when I eat...Read more...

My first week in Dec was good I suffered from chronic hunger I'm a gastric bypass person with more weight to lose. I'm not diabetic. I had the first bottle from (Utah) Compound pharmacy mailed to me did great little to no side effects. The hunger went away completely. First month TZ 2.5 from a compound pharmacy in pharmacy in my state instant injection site rashes very itch and blotchy. Found they use B6 in their mix. My MD said I can stay on 2.5 or move to 5 so I tried 5 and again bad injection site rashes needing treatment. Went back to 2.5 still same rashes and worse nausea and cramping. My own experiment I'm going back to the original compound pharmacy that only uses TZ with no other ingredients. It's odd because B6, B12 and glycerin are supposed to be useful in the TZ.

I haven’t had any serious side effects. Some GERD with some god awful taste and waves of queasiness mostly in the day after I do the shot. That’s it so far and 5 weeks. I’m moving up to 5mg today so we will see.

Fatigue and some nausea - this is pretty common. Some places even mix their sema or tirz with B12 to help offset this very common side effect. Eat high protein, simple foods if you can. Avoid greasy food. Drink lots of water as others have said. I didn't notice much in terms of skin, but the fatigue was noticeable for several weeks to me.

Im currently in my second week of tirzepatide and I injected in my leg this time and haven’t had any nausea side effects so far, however I do feel much more tired today and I can’t tolerate sweet drinks. I usually drink Ghost protein and lemonade drops and today I just couldn’t tolerate any sweetness and had to toss my protein shake and my water. My tastes for things are different, like I crave rye toast and bacon, tuna and mayo, and loved the sesame seeds on the rye bread so much I was picking them off the plate 😂

I'm sorry you are having these side effects. Had my 4th shot Thursday of 2.5 mg compounded Tirzepatide. No muscle or mental problems, no fatigue. Only slight nausea the first couple of days three weeks ago. However, as I mentioned to another poster, my hunger has not diminished significantly like others are reporting. I thought my face looked dry this morning and I was even using a new, not cheap, nigh-time moisturizing mask. So, it was interesting you mentioned the dry skin. I know I definitely need to drink more water.

Major benefit of Tirzepatide Hi all, just trying to wrap my head around tirzepatide and my response. I’m a couple doses into tirzepatide and have had great response as far as food noise and satiety. I’m only on the 2.5mg dose. Weight loss is coming from calories in vs out, correct? So as long as I feel appropriately managed, I should stick to 2.5mg, right? I would love to see the pounds melt off, but as long as I’m seeing ~1 pound/week, I think I’m ok with that for now.

No matter what , every single person will react different to the medication. For me I had extreme fatigue before I started tirzepatide , always felt sluggish , & the medicine actually gave me energy and I haven’t felt this good in a couple years . I started in August 2024 , SW 216 CW 171 GW 165 . I did 2.5mg for 4 weeks , and have been on 5mg this whole time . I’m loosing weight still but slowly now , and I don’t plan to move up in dose since I’m so close to my goal weight , unless I completely hit a plateau. First few weeks of medication I would get migraines the day of the shot and It was hard eating anything since I nothing seemed appealing . Those are the only side effects I recall , I haven’t had migraines since probably October ,...Read more...

I just took my 3rd shot of the 2.2mg. I've stalled at about 2 lb loss even though I've incorporated walking. Will start. 4.4 after another week. I'm hoping it makes a difference. Any thoughts? The only thing I've experienced.is heartburn. I did have pain at injection site this time around but probably because.ive been using the same area.

I am so tired of being sick! Started on tirzepatide 14 weeks ago - the usual small doses increasing every 4 weeks. No matter what I read on user sites, I cannot get my GI system settled. Nausea, sulfur burps, diarrhea, reflux, ugh. Have lost weight and was trying to hang on to lose another 10 lbs but not sure I’m going to make it. I’m using any recommendations I have read but cannot feel “good”. Is it just me or are others walking around half sick?

I've been on a similar journey and can relate to some of what you're describing, especially the fatigue and adjustment period. I get my Trizepatide from Amazing Meds, and it's been a game-changer for me. I also had some of those side effects early on, but they've definitely subsided as my body has gotten used to the medication. It's great that you're already feeling better in some ways, and I hope things continue to improve for you!

Well, I had almost every single side effect one could possibly have. I had really bad acid reflux and nausea. I vomited probably three times the day after one of the shots. I’m on week 18 now and I’m titrating up to 12.5 in another week. I’ve lost 17 pounds which is slow I know, but I’m only trying to lose 20 more. I’m glad I stayed with it because nothing else was working. I could starve myself and not lose weight, I could work out till I was gonna fall over and it didn’t help. The exhaustion was almost unbearable but now I feel really good. I don’t know why it took me four months to get here but I’m here. Bonine works very well for nausea.

I know this is an old post but just came to say I’m on day 3 after the shot and this is miserable lol. No energy, nausea, loose stools, shakiness, body aches. I hope it’s worth it though

3rd day after first injection and I haven't stopped having nausea. No vomiting. But the nausea, fatigue and muscle pain has been nearly been impossible to work with. Im not sure if I can go the distance if this keeps up. Its almost overwhelming. Hopefully it calms down as the dose dissipates but im not excited about next week's shots.

I'm at the end of my 2nd week, getting ready to take my 3rd shot tonight. 2.5mg. I'm kind of amazed, but will wait to see. I was freaked out at first because I'm more hungry, find that I'm eating regularly, and have lost 9lbs in 2 weeks. I have PCOS, and so, I've always had a balanced, high fiber/mediterranean diet and no matter how much I would work out or fast, there was not significant change. Previously I could not lose weight with intermittent fasting, and I wouldn't have much of an appetite after eating breakfast. I can only assume that metabolic shifts are working and my body is able to burn fat and intake my BMR caloric requirements without immediately storing them as fat. But it is still early. I haven't felt any different yet except for a bit less brain fog which is amazing. Physically I feel...Read more...

I've been taking Terzepatide  for 1 week now. First nights of sleep were very little sleep/ no Rem sleep. Once that pit in my stomach disappeared,  the sleep became a little better with help of Magnesium  Glycanate or Melatonin. Appetite is suppressed and has allowed me to say no to fried foods, fast food etc . I've lost 4 lbs this first week, but then I'm over 200 lbs. During the day if I hadn't get adequate  sleep I feel sluggish yet awake. I'm going to proceed with Tshot for a while to see how well it works for me. Active with job but no exercising.

My Tirzepatide Journey: Week 1 Recap Hi guys! 🌸 I just wanna share my tirzepatide journey for those who are thinking of starting this treatment! 😊 I hope this helps you guys and gives you an idea of what to expect. Here’s how my first week went: **Day 1 - Saturday:** At 3pm, I took my very first 2.5mg shot. Honestly, nothing unusual naman. So the rest of the day went pretty smoothly. Weight: 87kg. **Day 2 - Sunday:** This one was a bit of a hassle. I woke up feeling kinda hungover, but I thought maybe I just didn’t sleep enough. But the feeling lasted the WHOLE day. Every time I tried to eat, I felt like I was gonna puke. 😩 It was the worst feeling of dizziness ever! (I was honestly thinking about going to the ER, ha!). But good thing, Pocari Sweat and salt helped a...Read more...

I know this is an old post but just came to say I’m on day 3 after the shot and this is miserable lol. No energy, nausea, loose stools, shakiness, body aches. I hope it’s worth it though

Tirzepatide: A surprising Benefit (Not Medical Advice) I had a TBI several years ago. For a while, it was rough. I went from being fairly placid and easy going to being short tempered and melting down at over stimulation. I recovered quite a bit, but I was still definitely not like how I used to be. A few months ago I started tirzepatide to help with weight loss, among other goals. Over a few months I noticed my mental clarity had started improving substantially. I talked to my concussion doctor, and she believes my improvement is due to the anti-inflammatory effects in tirzepatide. It really feels like I'm finally getting a part of myself back. My mental stamina is much improved and I'm more mellow. Note: This is not medical advice. Tirzepatide seems to have helped me--according to my doctor--but there is no knowing how it would help anyone else.

I lost 25lbs with Tizep and lost another 10lbs after getting off. I got off thinking my sleep was being effected but it wasn't. I see the problem as this... 1. People try to lose more than 1lb of weight or 1% a week. I saw this on the subreddits and it was stupid. These people took years to put on the weight but want the solution quickly within weeks and months. 2. They eat processed garbage on the drug and don't change their lifestyle at all. Any time I eat processed food, its just not filling. I remember a post about eating only 3 MdC sheeseburgers a day. Seriously.. 3. They dont believe in CICO, they think the drug works in magic ways. Its an incrediable drug but 90% of its action is slower gastic emptying and reduced food noise so you eat less. 4. They expect weight loss...Read more...

I had pain reduction (from hEDS) right away, at the smallest dose (2.5mg). I had chronic trigger thumb that began healing when my dosage increased (I think at around 5-7.5mg). My MCAS triggers improved when I reached around 7.5mg. My daily burning mouth completely disappeared. I also noticed a decrease in my severe reactions to fragrance. Unfortunately, all of that progress was destroyed when I was forced to go on an antibiotic. Since then, my MCAS is significantly worse and has not improved, despite increasing my Tirzepatide to 10mg. Before the antibiotic, the improvements I felt on Tirzepatide were almost life-changing. I’m just hoping to get there again.

I’m on 1.5 mg Tirz. It’s helping a ton but I do have side effects. Started on .9 mg and pain relief began about 2 weeks in. Mast cells much less sensitive around week 3. I really struggle with days 2 and 3 after the shot with fatigue and nausea, just unable to eat, which eventually causes adrenaline spikes and insomnia. I’m figuring it out and might try split dosing of my tiny dose.

I overnight dropped 9lbs in water and inflammation on the smallest dose. I’m doing cash pay and I don’t regret it

Tirzepatide/GLP-1 caused 85% improvement **TLDR: Summary** Tirzepatide has given me an 85% improvement after 15 years of moderate to severe ME/CFS and trialing 20+ other meds that either didn't work or only gave me a 1-3% improvement. **Long Format Below:** *For those able to read and would like more detail* I know GLP-1's have been talked about a lot lately and I didn't want to write this post because I hated 'recovery' stories. After 15 years of hell, I never thought it would happen to me. But tirzepatide has changed my life. So I'm putting myself out there (please be nice), to share my experience in case maybe it helps someone else. BUT I am conscious that for the vast majority, like almost all meds, what works for one doesn't work for another. This is just my story. I am a 44 year old female with onset after unknown viral...Read more...

So frustrating. My husband is prescribed Wegovy for his heart condition. He pays a co-pay of $325 per month. Yesterday was the second time in 6 months he was told it’s out of stock and they don’t know when it will be in stock. Last time he waited 5 weeks. I reported the shortage to FDA and just got a form letter reply. I take Tirzepatide. Though I’ve always struggled with my weight I’m not eligible for the prescribed medication as I don’t have a qualifying chronic condition. Yet this medicine, which I pay for out of pocket has improved my overall health and lifestyle dramatically. I’ve lost (& kept off) 58 pounds. It’s given me my life back. I’m not going without it.

I had nausea with my first pregnancy and Tirz didn’t affect me very much at all. I had some nausea but it came and went. With my 2nd shot, I had no nausea.

I only had 30-40 to lose. I started tirz at 1 mg every five days in November. Currently I’m only up to 3 mg every five days. I’ve lost 33 lbs which is 19% of my body weight. Most of the weight came off in the first four months. Now I lose maybe 2 lbs a month and I’m actually good if I don’t lose any more. Stay hydrated, eat protein. Stick with a pretty healthy diet. Eventually you’ll try some things that are questionable. You may or may not have a bad night afterwards. It may or may not convince you not to do it again. I really didn’t have any nausea at any dose unless I overate. At the beginning I have an occasional night of painful gut issues. Maybe three or four nights total in the first two months. I got sulfur burps pretty early on. Papaya...Read more...

Are you me?? I was also very afraid of this. I was super nauseous during both of my pregnancies and then tried naltrexone to curb drinking (beer, ugh, the calories) to lose the 50 lbs I had gained. Naltrexone made me incredibly nauseous. Two weeks ago I finally took the leap and tried 2.5 mg of tirzepatide after a small amount of cajoling from a doctor. I’m 3 years pp and at the rate I was going the 50 lbs would stay forever. Well, I have not had nearly the extreme side effects or much unpleasantness at all. I would say it is absolutely tolerable and completely worth it. I’m already losing a little weight, not over eating, and focussed on eating better because I am eating so much less. I know it’s not the same for all, but you don’t know if you don’t try.

I stocked up on anti-nausea tools like ginger chews and a product called Tummy Drops which is a fruit-flavor ginger-ish lozenge. Those were very helpful keeping nausea at bay. Also changing injection site helps. My thighs were less nauseating but eventually moved to my stomach. But every once in a while I feel ick and the next week I go back to my thigh to lighten the effects. I started at 2.5mg for 4-5 weeks and when I titrated up I did .5mg per week increase until I got to 5. I’m still between 5 and 6mg right now and have been on for 6 months, down 47 pounds. The reason I go between 5-6 is dependent on me needing a little more push that week or if I want to enjoy something a little more. For example I’m going on a cruise next week - still taking the dose...Read more...

I recommend starting with a microdose. I started at .5 mg and after 12 weeks I’m at .8 mg or so with great results and minimal side effects. It’s not for everyone but at the very least, you’ll give your body time to adjust so you’ll have less side effects hopefully. 🤞🏻

Hello! I was scared to try tirz too because I assumed there would be bad side affects. I’m 7 weeks in now and I’m so happy I decided to give it a try. I’m currently on 5 mg. The only side affects I have are GOOD side affects. Appetite is heavily suppressed, no cravings for ANY junk food/fast food/alcohol etc. I also just quit vaping and haven’t gained any weight from quitting. I have lost a total of 18 lbs in 7 weeks. I have also been way more motivated to work out. My advice to you is TRY IT! Stock up on protein and protein shakes. Also electrolyte drinks have been super helpful. You will need to drink plenty of water and electrolytes. They help you from feeling fatigued and prevent dehydration. I feel very full after eating a small/childs serving of food. I focus on Whole Foods, fiber...Read more...

For me, this is my second month, it seems like I had least side effect of stomach cramp and nausea when I inject in the more fattier part of body (belly) vs my outer thigh. Also, food aversion is real. I threw away bags and bags of snacks because I don’t want to eat anymore (but it showed me how much food noise affected me before, how much snacks I accumulated). I had fainted once, the doctor told me it was dehydration since I don’t eat and drink enough, causing not enough blood oxygenated my brain. So I try to drink a liter of water a day mixed with a pack of Liquid IV to replenish the electrolytes. For food regularly, I make myself eat an avocado in the morning, make a protein shake from protein powder (I’ve tried both IsoPure and Vital Proteins Collagen peptides, good with no flavor)...Read more...

If you search on this page lots of providers come up. I use pomegranate health, It costs about $140 a month, but I am still doing a lower dose, I increase my dose when my weight loss stalls a couple of weeks. My goal is 4-5 pounds amonth. I've been on compounded tirz since mid October, have lost 21 pounds and am currently taking 5.5 a week.

Joey Med! Two months is $299 – already two weeks in and I am amazed at how much energy I have – already down 6 pounds. Ozempic made me feel sick & dead, and I didn’t lose any weight!

3rd day after first injection and I haven't stopped having nausea. No vomiting. But the nausea, fatigue and muscle pain has been nearly been impossible to work with. Im not sure if I can go the distance if this keeps up. Its almost overwhelming. Hopefully it calms down as the dose dissipates but im not excited about next week's shots.

I’ve only been on for 3.5 weeks. I take an antihistamine before my shot because I was really itchy the first couple shots. That has dissipated over time. I also take Tylenol with the injection because I get a headache on the day of injection. I started out on tiny doses and increased week by week so the side effects were more manageable. I also take GI Natural from NaturesPlus with meals to help with digestion. I haven’t had any burps, gas, or constipation yet. I’ve just made it up to .125 injection of 20mg/ml. I have fatigue but I’ve been able to work thru it and it gets better every week. Exercise, you don’t want to loose muscle mass so keep up your weight training and cardio. I’m down 2lb since starting, not much but I’m glad I have myself the grace of time to get used to this...Read more...

Everyone is different. My first dose was 1.25mg and it was way too much for me. I eventually restarted at .25. I’ve lost 13 lbs, only wanted to lose about 15. Other people feel nothing even at 2.5mg. So it’s all individual.

it's less risky to go up slowly - it just depends upon your tolerance for feeling bloating/nausea/fatigue for a week if it's too high. no one can know for sure. most ppl i know microdosing start at .25 or .5mg tirz. I think 1.25 is a little high. i have two friends with unbearable side effects over 1.0. first week .25 i had bloating and slow motility. second week .5: i am extremely hungry for protein. motility is ok. overall feeling better but i think it's just less to deal with at once if you go up slower.

I started at 1.25mg and it was the perfect dose for me. Lost 20lbs on it over the course of abt 2.5mo with minimal nausea and constipation, both of which are avoidable if I eat clean protein, fibrous greens, and take my supplements as needed.

I did! I just took my second shot of 1.25 on Saturday. Minimal side effects the first dose- took a few days to notice food noise was dampening, and it seems to be more effective the second week. Biggest side effect for me was constipation so I’m trying to stay ahead of it with hydration, fiber, etc. I want to lose about 40lbs and don’t mind going slow- I have good muscle and healthy bones and having just turned 40, want to keep them that way! I’m finding the med is working perfectly to shut off cravings but not so much that I can’t eat the food I need.

I started on 1.25mg of compounded tirzepatide and experienced a bit of nausea after the first couple weeks of injections, drinking water and eating protein in the morning helped curb the nausea. I noticed pretty quickly my appetite wasn't being as suppressed as i wanted and i wasn't really losing any weight, i ended up going up to 2mg and have been on that for abut 10 weeks and down 10 lbs! My goal is to lose another 10 lbs so i plan to stay on this dose. Like others have said it all depends on your bodies response, I think starting at 1.25mg is reasonable and if symptoms are too intense you can always adjust your dosage, on a lot of subs for glp1's people suggest even splitting your dose to 2 times a week instead of one to help with symptoms. If you are taking tirz where you...Read more...

I started at 2.5mg with zero issues and very little weight loss. I will begin the 10.0 dose this week. I am down about 20 pounds in 16 weeks.

I started at 1.25 last February with the hope of staying low because I’m sensitive to medications, but turns out my body needed more of the medicine ended up coasting at 7.5mg and I’ve lost 32lbs. Feel fantastic. Microdosing works well for some and others benefit from higher doses.

I am using Zepbound off label for intercranial hypertension. I started with 2.5 mg and had some side effects (not horrible) and then it wore off by day 4 and I would get a migraine, so I switched to 1.25 mg twice a week. I have no side effects with 1.25 mg. I inject in my thighs because it seems like more people have side effects with stomach injections and I wanted to avoid that. I lost 8 pounds my first 4 weeks.

I started at .5 and stayed there for a few months while I was losing. I’d lost about 12 lbs in three months before I increased the dose incrementally to drop the last few. I would say that is probably better to start low and go up then start too high and have to dose back down.

My cravings were gone the next day. I lost a dress size each month for 5 months and met my goals. With Tirzepatide I have kept it off for more than a year now.

I started 1.25mg tirzepatide on Dec 26th. My schedule is to take it Friday evening before I go to bed… so if there is side effects, I have the weekend to go slow. The first injection I just had muscle soreness. The second injection, I felt mild body achy like a cold on that Sat afternoon after running errands and cleaning. I am very active with workouts and I have to eat protein like hard boiled eggs before I try any activity. All and all I would say it has reduced noise for food, drink, and actually anxiety for me at the moment. I am enjoying it and will probably stay here as long as 1-2 pounds a week pending I can keep up with my workouts and protein. Hope this helps. Good luck on your journey and take advantage of the good habits it helps build.

I started at 1.25 and stayed there for about a month. My side effects were slight nausea and a bit of acid reflux if I ate too much. At first I had no food noise whatsoever. In the 2nd week it started to creep back in, but was bearable. The 3rd week, by day 4 the food noise was worse. I titrated up at week 4 to 1.75. Still a very low dose. This is the first week at that level and want to give it time to build up in my system before I re-evaluate, but, everything is going as it did in week 1 of 1.25. Oh, and constipation. As far as minimizing side effects, drinking cold ginger tea with lemon helped me with the nausea. For the constipation I use Mag O7 and Senecot. As long as I don't let the constipation get ahead of me this...Read more...

Started at 1.25mg and still at 1.25mg . I’ve had 9 injections so far . Lost 15 lbs so far but my inflammatory issues are way down!!

.4 mg on week 3 and my appetite is shockingly suppressed. I just purchased more clean superfood protein powder and a portable ninja blender so I can get in more protein since I’m not a meat eater and constantly on the run. Maybe try lower to start and see how you react? I’m shocked at what appears to be such a quick response.

I tried 1mg and it was way to much so moved to .5 twice a week. Get an rx for zofran, magnesium for constipation and something to help you sleep. I also had a lot of fatigue

I started at 1.25, and it's completely fine for me. Minimal side effects and effective appetite suppression. I'm normally quite sensitive to medication but 1.25 was completely unproblematic for me.

I started at 2.5, and tirades up very slowly, highest I ever went was 4.0 and hit my goal weight. Lost 32 lbs. Titrated back down to 2.5 where I have been maintaining for 3 months. Currently every 12 days. I think you are smart to start at 1.25. Better not to rush it and get side effects. Keep us posted!

I started 0.25 and am now at 1.75. I’ve been on it for over 3 months. Inflammation great but zero weightloss. I have 40kg to lose.

I started at .5mg and felt nothing. So then I went up to 1mg and that was WAY too much. I found my happy medium at 0.75mg once per week. Down about 6 pounds so far and started about 5 weeks ago. I will likely jump up to 1mg in the next two weeks b/c I am starting to crave sugar around day 5 after I take the shot. The food noise is creeping up around day 4/5.

I had minor nausea (mainly from empty stomach) and fatigue on the first few days after shot. Now, 14 shots in, those side effects are gone and now working to treat a bit of constipation. Water, water, water. Drink the water!

I am on week 3 of Tirzepatide, this coming Sunday will be my 4th shot. Week 1, nothing. Week 2 I started to notice that my hunger and cravings were reduced and when I would eat, my portions were smaller. After starting Week 3 this past Sunday, I have noticed more that I can go a long time without even thinking about food. It was recommended to me that if you are cutting out Soda/tea/coffee that you would get headaches. To help combat that, you need to either drink some salt water or add sodium somewhere. I started adding the Liquid IV packets to my bottles of water everyday and that has been awesome! For fatigue- Are you also taking B-12 shots? I added those to my weekly injections as well and it helps for sure. Lastly, starting this week (3), I began to notice bowel issues when I eat...Read more...

My first week in Dec was good I suffered from chronic hunger I'm a gastric bypass person with more weight to lose. I'm not diabetic. I had the first bottle from (Utah) Compound pharmacy mailed to me did great little to no side effects. The hunger went away completely. First month TZ 2.5 from a compound pharmacy in pharmacy in my state instant injection site rashes very itch and blotchy. Found they use B6 in their mix. My MD said I can stay on 2.5 or move to 5 so I tried 5 and again bad injection site rashes needing treatment. Went back to 2.5 still same rashes and worse nausea and cramping. My own experiment I'm going back to the original compound pharmacy that only uses TZ with no other ingredients. It's odd because B6, B12 and glycerin are supposed to be useful in the TZ.

I haven’t had any serious side effects. Some GERD with some god awful taste and waves of queasiness mostly in the day after I do the shot. That’s it so far and 5 weeks. I’m moving up to 5mg today so we will see.

Fatigue and some nausea - this is pretty common. Some places even mix their sema or tirz with B12 to help offset this very common side effect. Eat high protein, simple foods if you can. Avoid greasy food. Drink lots of water as others have said. I didn't notice much in terms of skin, but the fatigue was noticeable for several weeks to me.

Im currently in my second week of tirzepatide and I injected in my leg this time and haven’t had any nausea side effects so far, however I do feel much more tired today and I can’t tolerate sweet drinks. I usually drink Ghost protein and lemonade drops and today I just couldn’t tolerate any sweetness and had to toss my protein shake and my water. My tastes for things are different, like I crave rye toast and bacon, tuna and mayo, and loved the sesame seeds on the rye bread so much I was picking them off the plate 😂

I'm sorry you are having these side effects. Had my 4th shot Thursday of 2.5 mg compounded Tirzepatide. No muscle or mental problems, no fatigue. Only slight nausea the first couple of days three weeks ago. However, as I mentioned to another poster, my hunger has not diminished significantly like others are reporting. I thought my face looked dry this morning and I was even using a new, not cheap, nigh-time moisturizing mask. So, it was interesting you mentioned the dry skin. I know I definitely need to drink more water.

No matter what , every single person will react different to the medication. For me I had extreme fatigue before I started tirzepatide , always felt sluggish , & the medicine actually gave me energy and I haven’t felt this good in a couple years . I started in August 2024 , SW 216 CW 171 GW 165 . I did 2.5mg for 4 weeks , and have been on 5mg this whole time . I’m loosing weight still but slowly now , and I don’t plan to move up in dose since I’m so close to my goal weight , unless I completely hit a plateau. First few weeks of medication I would get migraines the day of the shot and It was hard eating anything since I nothing seemed appealing . Those are the only side effects I recall , I haven’t had migraines since probably October ,...Read more...

I just took my 3rd shot of the 2.2mg. I've stalled at about 2 lb loss even though I've incorporated walking. Will start. 4.4 after another week. I'm hoping it makes a difference. Any thoughts? The only thing I've experienced.is heartburn. I did have pain at injection site this time around but probably because.ive been using the same area.

I am so tired of being sick! Started on tirzepatide 14 weeks ago - the usual small doses increasing every 4 weeks. No matter what I read on user sites, I cannot get my GI system settled. Nausea, sulfur burps, diarrhea, reflux, ugh. Have lost weight and was trying to hang on to lose another 10 lbs but not sure I’m going to make it. I’m using any recommendations I have read but cannot feel “good”. Is it just me or are others walking around half sick?

I've been on a similar journey and can relate to some of what you're describing, especially the fatigue and adjustment period. I get my Trizepatide from Amazing Meds, and it's been a game-changer for me. I also had some of those side effects early on, but they've definitely subsided as my body has gotten used to the medication. It's great that you're already feeling better in some ways, and I hope things continue to improve for you!

Well, I had almost every single side effect one could possibly have. I had really bad acid reflux and nausea. I vomited probably three times the day after one of the shots. I’m on week 18 now and I’m titrating up to 12.5 in another week. I’ve lost 17 pounds which is slow I know, but I’m only trying to lose 20 more. I’m glad I stayed with it because nothing else was working. I could starve myself and not lose weight, I could work out till I was gonna fall over and it didn’t help. The exhaustion was almost unbearable but now I feel really good. I don’t know why it took me four months to get here but I’m here. Bonine works very well for nausea.

I'm at the end of my 2nd week, getting ready to take my 3rd shot tonight. 2.5mg. I'm kind of amazed, but will wait to see. I was freaked out at first because I'm more hungry, find that I'm eating regularly, and have lost 9lbs in 2 weeks. I have PCOS, and so, I've always had a balanced, high fiber/mediterranean diet and no matter how much I would work out or fast, there was not significant change. Previously I could not lose weight with intermittent fasting, and I wouldn't have much of an appetite after eating breakfast. I can only assume that metabolic shifts are working and my body is able to burn fat and intake my BMR caloric requirements without immediately storing them as fat. But it is still early. I haven't felt any different yet except for a bit less brain fog which is amazing. Physically I feel...Read more...

I've been taking Terzepatide  for 1 week now. First nights of sleep were very little sleep/ no Rem sleep. Once that pit in my stomach disappeared,  the sleep became a little better with help of Magnesium  Glycanate or Melatonin. Appetite is suppressed and has allowed me to say no to fried foods, fast food etc . I've lost 4 lbs this first week, but then I'm over 200 lbs. During the day if I hadn't get adequate  sleep I feel sluggish yet awake. I'm going to proceed with Tshot for a while to see how well it works for me. Active with job but no exercising.

I think you can!  If you listen to Dr Tyna it depends on how metabolically sound you are.  I already knew that I was doing a lot of different things right and simply not able to shift the weight. I did start at 2.5 but now looking back I wish I had started at 1.5. The weight has been coming off, I feel fantastic and there have been no side effects and knock on wood it keeps going well. Started at 175, 4 shots in and now at 165, working out and eating really well (I count macros to be sure I’m getting 100 G protein and low cal), and lots of electrolytes. I think if you have the chance to start lower, it’s a great idea, you have nowhere to go but up .

I started on 2.5 tirzepitide two weeks ago. The fatigue and brain fog was crazy. I did 1.5 yesterday for my third dose and feel so much better. The fog has lifted! I'm still a little tired today, but nothing like before. I should have started lower. 

364 (364?) days on Tirzepatide and 149.5 lbs down from high weight and 140.6 down since starting SW 301.1 CW 160.5 HW 310.0 GW ??145?? started Jan 2 2024 44 y/o female 5’3” (I always thought I was 5’4” until recently) PCOS/insulin resistant One year ago I was peeping in on this sub, getting all the tips and tricks, seeing all these transformations and preparing for my first shot. I fantasized about hitting 169 which would have put me JUST into overweight from obese on the BMI chart. I thought it was a ridiculous, unobtainable goal. I set my “probably realistic” goal to 215 which was 1lb less than I’d been in my adult life. My “let’s be honest with ourselves and not set me up for disappointment” goal was 240 or really ANYTHING. I never ever thought I’d hit my ridiculous unobtainable goal. I never ever thought that I’d...Read more...

(27) to (30) Over the span of two-three years (and my 2nd pregnancy!) I’ve lost 165 pounds. I wanted to show my kids that we CAN do hard things. I weigh all my food and stick to 1500 calories daily. I used the minimum dose of Tirzepatide for a few months, but unfortunately I had severe side effects, some of which I’m still dealing with. I am thankful that it helped me get my mindset right and got me started on my journey. I have learned to love weight lifting and am closing in on my goal.

(27) to (29) Trying this again because my first post got removed. Over the span of two years (and my 2nd pregnancy!) I lost 135 pounds. I wanted to show my kids that we CAN do hard things. I weigh all my food and stick to 1600 calories daily. I used the minimum dose of Tirzepatide for a few months, but unfortunately I had severe side effects, some of which I’m still dealing with. I am thankful that it helped me get my mindset right and got me started on my journey.

I’m a super responder, so my experience is relatively uncommon: Personally, my appetite was crushed the morning after I took my first shot the evening before. 68 pounds down in a little under 6 months, all on 2.5mg: Month 1: -32.4 lbs Month 2: -19.1 lbs Month 3: -9.3 lbs Month 4: -4.9 lbs Month 5: -1.5 lbs I used to drink 60+ beers a week, then hangover binge 5000 calories of McDonald’s the morning after, buy a bunch of snacks at the gas station then go home and lay in bed all day watching TV while snacking on garbage. On weekdays I’d start off with 2 breakfast sandwiches in the morning, then a Wendy’s triple cheeseburger for lunch and some garbage for dinner. All that has changed. I’ve been sober since I started the shot, and don’t crave beer anymore. The bar I used to frequent for hours is...Read more...

I’m in my 3rd month. I started responding to tirz right away. I had appetite suppression that started later that night, which ebbed and waned over the following weeks. I then noticed that whenever I went to the bathroom, my pants slid way more smoothly over my hips and butt. I’ve lost 21 pounds, and still over 200# at only 5’ tall, so I’m the only one noticing those body changes yet. But I’m thrilled with that and look forward to the weight I expect to lose.

I noticed appetite suppression and food noise reduction the morning after my first shot. I lost 4 pounds the first week. Lost 30 pounds overall in 4 months.

I started last week of oct 2025, I noticed changes 2 months after (being on 5mg 3rd week), appetite suppression is noticable, food noise is weaker, people started to notice I'm losing weight, scale shows I lost 7-10 (fluctuates). Didn't developed side effects such as nausea being on tirzepatide, even now on 9mg.

Changes in appetite immediately. Within 12 hours I was fully suppressed. I dropped 20 lbs in my fist 2 weeks so I could feel the difference by then but results were visible within the first month (30 lbs) and especially by month two (47 lbs). Currently down 80 lbs which I reached around month 6-7. I started losing a lot slower over summer do to social activities and just getting closer to goal. I am at my goal weight essentially but might lose another 10-20 lbs.

I ordered my first Tirzepatide the day before Thanksgiving, as of yesterday I am down 34.2 lbs. I have done seven doses at 2mg and one at 2.5mg. Most of the loss seems to be in my abdomen.

Right away.. didn't think much would happen in the 1st month per my Dr. But down 20LB and the inflammation on my body has gone from feeling like a bruise everywhere to almost like a deflated balloon. It's a great feeling not to feel sore and heavy everywhere.

I take my 2nd shot tomorrow. Zepbound pen 2.5. I felt food noise go down by the day after the shot. I had a greatly reduced appetite and am struggling to get in even 1200 calories a day. Definitely have not increased my water intake enough. I felt nausea the first day of my shot through the 4th day. It is day 6 and I just noticed I have been in bed a lot and haven't felt like getting up or doing anything which is not like me. I have skipped my regular house chores and haven't been working my business. Is this something that some get? I am looking forward to my 2nd shot tomorrow to see if this lack of motivation goes away! I have lost 5 lbs in the first 6 days which looks great on my scale! No body changes yet.

Just a little backstory - I am a 45 year old woman, with insulin resistance and PCOS. My highest weight was 253 pounds at 5'5", when I was 24. I was given metformin at that time, and lost 30 pounds in 6 weeks. I tried over the next several years to lose more weight, and had varying success. I tried everything from Keto, phentermine, to doctor monitored liquid diets of 800 calories a day. In 2017, I got down to a healthier weight (150lbs), was no longer considered overweight/obese, then stopped trying to maintain. Slowly, very slowly, I gained back up to 204lbs as of 08/29/2025. Something had to change, and it was me, I had to change. I started Tirz on 09/1/2025 at the usual 2.5mg dosage, and noticed an immediate difference. As in the same day, I felt effects. Within the first week of my first injection, I...Read more...

Why have most people started at 2.5 mg but my instructions were 0.08 mg now I am up to 0.15 for the next several weeks than I move up to 0.30 just curious seems like that is a low dosage but I have seen a difference in my appetite and I have lost some weight!

First day I had less food noise and appetite suppression. I’ve lost 10 lbs in first 3 weeks. That being said I’m watching macros closely and working out 6 days a week. I have a total of 60 to lose. Edited to add- I am 5ft6 with an athletic build. I have a lot of muscle under my fat. I can see and feel the difference and my husband says he can too. Others probably wouldn’t notice yet. I am an all over all at once when I shed fat so it takes a bit longer to notice vs people who lose it all off their gut first or something like that. I wish I could choose where it comes off first lol

I don’t have much weight to lose (15 lbs) or so and I noticed my body felt better at week 2, no food noise, a few lbs a week or so, I’m now down 9 lbs on week 5 and I am feeling so much better in my clothes and my lower back doesn’t hurt as bad which that in itself feels so great ! Good luck!

My daughter and I compared notes and we both had hunger noise completely gone the day after our first shot. I lost 13 pounds of presumably water weight and inflammation the first week and she lost five.

For me, appetite changes came pretty quickly within the first 1–2 weeks. Visible body changes took a bit longer, around 4–6 weeks, and really picked up after a couple dose increases. It is gradual but one day you realize clothes fit looser. Everyone’s timeline is different though

I'm still relatively new, I take my last 2mg dose tomorrow so it's been about 3 weeks. I've had minimal loss on the scale (maybe 5lbs?) but definitely body comp changes. I tend to lose around my face, neck and arms first for whatever reason and they absolutely feel smaller. All of my jeans fit better and I can even wear them sitting down all day at work. I do strength train heavy 3 times a week though (I love powerlifting), so my experience will be different than someone who doesn't.

Everyone is different. So keep that in mind if your experience doesn't match everyone else's. I had a noticeable effect at the intro dose. Right away my intake went down by almost half and I got crazy gerd if I overate. But, at the intro dose I would also feel it wear off sharply after the five day half life. This was softened when I went up to 5. I'm currently planning to go up to 7 next week, but I think that might be my resting point for awhile.

The day after my first shot. 2.5mg. I noticed loss of appetite and a bit if nausea.

I’ve been on it for 8 months, up to a 10mg dose. I haven’t lost anything. I wasn’t an over eater to start with. I’ve been thinking of changing injection site to the thigh, instead of the belly like I’ve been doing. It did help with inflammation and cleared my skin, just no weight loss.

I took my very first shot ever 48 hours ago and am supposedly down 4.2 pounds so apparently I had a TON of water weight (zero exercise). Similar to others, the anorectic effect was noticeable almost immediately. First night after I took the shot at 10 am, I couldn't get anything down, yesterday morning I had some chicken breast and chicken broth (that took me until 2 pm to finish), then an egg and a few egg whites for lunch, and a single serving of buttered fiber pasta for dinner. I'll need to figure out some very calorie dense, low volume meals to compensate for the total lack of appetite.

I didn’t feel anything until 10mg and now I’m on 14 mg and usually feel some appetite suppression the first 2-3 days after and it slowly comes back.

I have not found each dose to be effective for 3 months but I have not done 10-15mg yet. I found 5mg to be effective for about 9 weeks. I moved up today due to overwhelming hunger. I fear the maintenance phase. The rebound hunger is going to be intense.

The lower doses werent great for me. I lost the most.in the first month on 5. I stalled in month 2 of 5mg. I didn't lose on 7 5. Loss really picked up on 10mg and I was there almost 4 months. I was on 15mg the longest of any dose- 6 months. The appetite suppression seemed tonget stronger the longer I was on it so I started tapering down a little before I was at target weight.

I think it’s probably very individual as to which dose works for how long on which person. A trial and error process. Went up in dose pretty regularly from May through Sept & hit goal on 12.5 mid Dec. I figure there’s only a certain window of opportunity where the medication is very effective and you have the momentum so I wanted to make the most of that timeframe. Never really had a dose become “ineffective” as I’ve always had very good appetite, control, and feeling full quickly. Sometimes my weight loss slightly stalled out and that’s when I would increase dose. I wanted to keep everything moving forward. https://preview.redd.it/t7yja8q6rvog1.jpeg?width=1125&format=pjpg&auto=webp&s=470ff7a4d5a8e4be380d89e5ea227d4a239a2636 Since Dec I have been spreading out the shots farther and farther apart, but continued to lose a little, so last week reduced my dose to 10 in an effort to stabilize my weight and I’m trying to eat more...Read more...

Started at 1.25mg and am finally up to 2.5mg - have lost 25 pounds in 6 months. One pound per week on average is a reasonable sustainable pace IMO. Any more and you are running large calorie deficits which is not super healthy. There are often weight loss plateaus along the way and then you should taper down off the drug which is more time. I don't see how you are going to accomplish much in one month.

I am going to try 2.5 mg as a lower maint dose. I started about 15 months ago, lost close to 50lbs, was on a 5mg maint dose and just wanted to maintain however I started having serious side effects with nausea and vomiting, most likely due to a reaction with the medicine in my intrathecal pump. I was trying to just quit but the food cravings were intense, so my doc said try 2.5 and see if it just quiets the cravings, maybe it will work as a maintenance dose I don't want to lose anymore weight, if i gain 5 to 10 lbs I would be fine with that. When i get these food cravings my stomach is starving and I try to feed the beast, and the digestion is still slowed down this causes a blockage and nausea and puking. Last week I ate a bunch of...Read more...

I’ve been on 2.5mg since October and have lost 25lbs so far (161lbs down to 136). I’ve been using it as a tool along w the gym to get weight off I gained in 3 years of grad school. I’m coming off it in June or when I am down to 128lbs, whichever comes first.

It took three weeks alone for the side effects to become bearable and the medication to build up in my system to be effective at the lowest dose. I also did not see any weight loss at this time. Cut to 14 weeks later still at the lowest dose and I have lost 9 kgs. My plan is to be on the meds for a year and then gradually wean myself off with staggered dosing per the latest studies.

Tirzepatide completely changed how I see obesity (including my own) I want to share something a bit personal because this medication has genuinely changed the way I think about obesity and about people who struggle with weight. For context, I'm 37F taking 2.5mg and on to my 6th week. Lost 11lbs so far. I was never obese. I’ve always been on the higher side of “normal,” and after having kids I became overweight and was on the verge of obesity. Food (especially sweets) was a constant struggle for me, even growing up. I could control myself for a few days, sometimes even a few weeks. I could diet. I could exercise. But I could never keep it up long-term. Eventually something in my brain would flip and I’d lose control again. It became worse and worse in the last few years. Growing up, I watched shows like The Biggest Loser...Read more...

6 months, 26 shots, and 128 lbs down — Tirzepatide has truly changed my life I started tirzepatide on May 8th of this year, and today marks about 6 months and 26 shots since I began. To say this medication has been life-changing is a huge understatement. In that time, I’ve hit so many milestones — not just on the scale, but in how I feel and live day-to-day. I have so much more control over my eating habits, and my relationship with food feels completely different. I have more energy, less joint pain, and honestly, more confidence than I’ve had in years. Stats: Starting weight: 458 lbs BMI 60.7 Current weight: 330 lbs BMI 43.5 Total lost: 128 lbs — about 28% of my starting weight Goal weight: 250 lbs Pant size: 58 > 44 Shirt size: 3–4X > 2X Current dose: 10 mg weekly (just increased last week)...Read more...

My Life Changed in 2025 🎉 I posted in another sub, but a kind person suggested I also post here in case it helps anyone. So here goes. ❤️ I started tirzepatide in Sept 2024 and I am now down 87 pounds from 222 to 135. I’m 55 years old, 5’9”. 2025 opened a whole new chapter for me, excited for 2026. Best wishes everyone!

Tirzepatide/GLP-1 caused 85% improvement **TLDR: Summary** Tirzepatide has given me an 85% improvement after 15 years of moderate to severe ME/CFS and trialing 20+ other meds that either didn't work or only gave me a 1-3% improvement. **Long Format Below:** *For those able to read and would like more detail* I know GLP-1's have been talked about a lot lately and I didn't want to write this post because I hated 'recovery' stories. After 15 years of hell, I never thought it would happen to me. But tirzepatide has changed my life. So I'm putting myself out there (please be nice), to share my experience in case maybe it helps someone else. BUT I am conscious that for the vast majority, like almost all meds, what works for one doesn't work for another. This is just my story. I am a 44 year old female with onset after unknown viral...Read more...

I’m a super responder, so my experience is relatively uncommon: Personally, my appetite was crushed the morning after I took my first shot the evening before. 68 pounds down in a little under 6 months, all on 2.5mg: Month 1: -32.4 lbs Month 2: -19.1 lbs Month 3: -9.3 lbs Month 4: -4.9 lbs Month 5: -1.5 lbs I used to drink 60+ beers a week, then hangover binge 5000 calories of McDonald’s the morning after, buy a bunch of snacks at the gas station then go home and lay in bed all day watching TV while snacking on garbage. On weekdays I’d start off with 2 breakfast sandwiches in the morning, then a Wendy’s triple cheeseburger for lunch and some garbage for dinner. All that has changed. I’ve been sober since I started the shot, and don’t crave beer anymore. The bar I used to frequent for hours is...Read more...

I’m in my 3rd month. I started responding to tirz right away. I had appetite suppression that started later that night, which ebbed and waned over the following weeks. I then noticed that whenever I went to the bathroom, my pants slid way more smoothly over my hips and butt. I’ve lost 21 pounds, and still over 200# at only 5’ tall, so I’m the only one noticing those body changes yet. But I’m thrilled with that and look forward to the weight I expect to lose.

I noticed appetite suppression and food noise reduction the morning after my first shot. I lost 4 pounds the first week. Lost 30 pounds overall in 4 months.

I started last week of oct 2025, I noticed changes 2 months after (being on 5mg 3rd week), appetite suppression is noticable, food noise is weaker, people started to notice I'm losing weight, scale shows I lost 7-10 (fluctuates). Didn't developed side effects such as nausea being on tirzepatide, even now on 9mg.

Changes in appetite immediately. Within 12 hours I was fully suppressed. I dropped 20 lbs in my fist 2 weeks so I could feel the difference by then but results were visible within the first month (30 lbs) and especially by month two (47 lbs). Currently down 80 lbs which I reached around month 6-7. I started losing a lot slower over summer do to social activities and just getting closer to goal. I am at my goal weight essentially but might lose another 10-20 lbs.

I ordered my first Tirzepatide the day before Thanksgiving, as of yesterday I am down 34.2 lbs. I have done seven doses at 2mg and one at 2.5mg. Most of the loss seems to be in my abdomen.

Right away.. didn't think much would happen in the 1st month per my Dr. But down 20LB and the inflammation on my body has gone from feeling like a bruise everywhere to almost like a deflated balloon. It's a great feeling not to feel sore and heavy everywhere.

I take my 2nd shot tomorrow. Zepbound pen 2.5. I felt food noise go down by the day after the shot. I had a greatly reduced appetite and am struggling to get in even 1200 calories a day. Definitely have not increased my water intake enough. I felt nausea the first day of my shot through the 4th day. It is day 6 and I just noticed I have been in bed a lot and haven't felt like getting up or doing anything which is not like me. I have skipped my regular house chores and haven't been working my business. Is this something that some get? I am looking forward to my 2nd shot tomorrow to see if this lack of motivation goes away! I have lost 5 lbs in the first 6 days which looks great on my scale! No body changes yet.

Just a little backstory - I am a 45 year old woman, with insulin resistance and PCOS. My highest weight was 253 pounds at 5'5", when I was 24. I was given metformin at that time, and lost 30 pounds in 6 weeks. I tried over the next several years to lose more weight, and had varying success. I tried everything from Keto, phentermine, to doctor monitored liquid diets of 800 calories a day. In 2017, I got down to a healthier weight (150lbs), was no longer considered overweight/obese, then stopped trying to maintain. Slowly, very slowly, I gained back up to 204lbs as of 08/29/2025. Something had to change, and it was me, I had to change. I started Tirz on 09/1/2025 at the usual 2.5mg dosage, and noticed an immediate difference. As in the same day, I felt effects. Within the first week of my first injection, I...Read more...

Why have most people started at 2.5 mg but my instructions were 0.08 mg now I am up to 0.15 for the next several weeks than I move up to 0.30 just curious seems like that is a low dosage but I have seen a difference in my appetite and I have lost some weight!

First day I had less food noise and appetite suppression. I’ve lost 10 lbs in first 3 weeks. That being said I’m watching macros closely and working out 6 days a week. I have a total of 60 to lose. Edited to add- I am 5ft6 with an athletic build. I have a lot of muscle under my fat. I can see and feel the difference and my husband says he can too. Others probably wouldn’t notice yet. I am an all over all at once when I shed fat so it takes a bit longer to notice vs people who lose it all off their gut first or something like that. I wish I could choose where it comes off first lol

I don’t have much weight to lose (15 lbs) or so and I noticed my body felt better at week 2, no food noise, a few lbs a week or so, I’m now down 9 lbs on week 5 and I am feeling so much better in my clothes and my lower back doesn’t hurt as bad which that in itself feels so great ! Good luck!

My daughter and I compared notes and we both had hunger noise completely gone the day after our first shot. I lost 13 pounds of presumably water weight and inflammation the first week and she lost five.

For me, appetite changes came pretty quickly within the first 1–2 weeks. Visible body changes took a bit longer, around 4–6 weeks, and really picked up after a couple dose increases. It is gradual but one day you realize clothes fit looser. Everyone’s timeline is different though