Effectiveness
Users report improvement81%
Side Effects
Reported side effects36%
Would Recommend
To others with same condition73%
Avg. Duration
Average reported usage duration3-6 months
Side Effects Frequency
Percentage of users reporting each side effect
Sentiment Analysis
User sentiment from reviews and feedback
Positive
54%Neutral / Mixed
20%Negative
26%Featured User Reviews
Recent experiences from users
DR
Mixed
3/12/2026
My 5 week experience on retatrutide
Before starting- 85kgs, 5’10
I have experienced the best and worst of reta.
I started with 1mg but like in a week changed it to 2mg for which I don’t have a valid reason I’m just stupid. I was good but my appetite had TOTALLY CRASHED. It was hard for me to eat more than one meal but it was still fine when Week 4 comes in. The worst week- I HAD SO MUCH NAUSEA AND I COULD BARELY WORKOUT.
Somehow I waited that week out with nausea meds and all and I decided to go back to 1mg as I wanna be able to eat too so I don’t lose all my muscle.
Tho in the past 5 weeks I lost 7.5 kgs
GREAT EFFECTS MENTALLY, GOOD CONFIDENCE BOOST
PU
Positive
2/28/2026
How are your energy levels? Do you feel more tired, normal, or more energized? more energized for sure it’s been easier to hit the gym. my metabolism is faster. • Does it affect your motivation to work out or recovery after the gym? yes more motivation to go to the gym. recovery i don’t notice a difference • Any changes in cravings, food noise, or relationship with food? no food noise at all. i still sort of have mental cravings but not the appetite for them. less cravings for greasy food. • How are the side effects compared to other GLP-1s like semaglutide or tirzepatide? i hated ozempic when i took it briefly. it made me feel nauseated by even the thought of food plus very tired. none of that with reta • Has it affected your mood, focus, or hormones at all? mood is better. but a little anxiety...
TH
Positive
9/22/2025
8 weeks on retatrutide – sharing my experience so far 💉 I’m currently in week 8 on retatrutide and figured I’d share a quick update. Started at a low dose (0.8 mg) and have been slowly titrating up — currently sitting at 1.2 mg weekly. The difference it’s made has been really noticeable: • Appetite suppression is real — food noise is basically gone. • Weight is coming down steadily without me feeling drained. • Early weeks had some nausea, but that eased up as my body adjusted. • Energy and recovery in the gym have been surprisingly decent. Honestly, I wasn’t sure what to expect going in, but so far it’s been a really good experience. Cost/access is obviously not simple, but it’s out there and a lot more manageable than what official channels will likely run once it’s mainstream. If anyone’s curious about the process, side effects, or...
MU
Negative
2/24/2026
Side effects are side effecting💔
Wth literally sobbing. I love reta shes a baddie bit uhm yesterday on day 3 the symptoms started attacking me💔 first it started with the worst punishment ever that will make you want to crawl in a hole because someone will point it out. SULFUR BURPS. They subsided earlier today but it was only after I started have extreme diarrhea 😀 are we dead ah rn😀💔 I literally havent been able to do anything today because I need to be near a toilet at all times. I will literally leave the bathroom and run back 5 minutes later💔.
Maybe its just locking in?? Idk but I started with 1mg dose and im like in shambles man
BO
Mixed
12/25/2025
1. Check the source
2. Check to make sure you reconstituted the correct amount
3. Double check the dosages
4. Lower dose if everything checks out
I’ve been running Reta with BPC157 which I think has helped some of the gut related issues I was having. First couple weeks were rough but tums seemed to help.
If I am struggling to eat I take a couple hits off the 🍁pen.
Also make sure to stay hydrated.
MA
Positive
7/18/2025
10wks in, 25lbs down. Been on 2mg since beginning just increased to 3 mg this week. The only side effects I've experienced is slightly elevated heart rate first 5wks and sensitive skin. Literally nothing else! I ❤️❤️❤️❤️ Reta. Life changing. Tons of energy
JE
Positive
4/2/2026
I have. I have had anger issues due to early childhood trauma most of my life. I do therapy, sleep, eat fairly healthy and practice tools to help with it. Nothing works like Reta. It’s my god send honestly. I feel like a totally different person. I now have the space inside to apply all the tools I learned in therapy to help when I do get upset now. But it’s better than night and day for me. It’s changed so much. I also cut back on weed and do not want a drink anymore, not that I really did drink, one or two beers if that. I can actively heat my brain talking about proper portion sizes and better choices. I’ve never been a two cookie guy but here I am saying no thanks after one…Reta has rewired me in so many ways. Sex and initiation is harder but...
JT
Negative
4/2/2026
I quit taking it because of no joy. Basically was finding no joy in the things I love. Worked extremely well for food cravings and losing weight though.
Ultimately I chose to stop because I really didn't have much more to lose and wanted my joy back. Took about a month to be fully back to baseline after quit.
CA
Positive
4/2/2026
Only real side I've experienced was hair loss from it working too well. Been losing weight at like 2 pounds a week so my hair got weaker. Viviscal and ghkcu has fixed it and my hair is growing back at a steady rate now and the hair loss halted. Def would start on ghkcu and collagen/vitamin c right at the start of reta if I could do it again.
NO
Negative
4/2/2026
i lost weight to fast and was under eating way to much (800-1200 calories) and my hair thinned like 50% so watch out for that. It goes back to normal just have to eat more (i’m eating 2,400-2,800) now.
CH
Mixed
4/2/2026
I have not been on it long. 8 weeks and 4mg, but I have not noticed a decreased food drive or anything other than some constipation, weight loss, some muscle cramps, and a bit less endurance than it’s jogging and weight training. Food is still very very addicting.
BR
Positive
4/2/2026
I've begun almost obsessively diving into peptides since starting reta....just over a month ago..and online shopping more than I should....I've had no desire to drink at all, food noise is gone ,down about 20#.. had been intermittent fasting for 90% of the last 2 years. Very ketovore style diet but this stuff just torches fat. Side note: also started tesamorelin/impamorelin-nad+/5 amino 1mq and glow. Don't know if my vyvanse is needed anymore because some days I feel.way overstimulated.....maybe my meds are too strong since I've lost about 65# last 3 years...but 20# in the last month...Retatrutide for all!!!
PO
Positive
4/3/2026
Some initial suppressed emotional affect, but that came back after about a week. Even after I upped my dosage. Start small, taper on, only bump dosage once the effects (weight loss only here) stops. 220->198lbs in two months. The weight loss there outside some water weight for muscle was less than 1%. 200 cal deficit and weightlifting 4-5 times a week cardio 4-5 times a week. 1mg every week with two doses per week. Bumped to 2mg twice a week after the 4th week. Off now feel normal, not shredded but definitely a significantly more tapered appeared and lost 2-3 inches of the waist.
SO
Positive
4/3/2026
I’m a woman and I’m on the highest dose of Reta. My sex drive is as high as it’s always been (which is regularly pretty high). Just need to find a partner 🤣. Reta helping me lose this little tummy is helping so I won’t feel so self conscious during sex. I also still enjoy drinking and food, but I just don’t desire to overdo it.
HE
Negative
4/2/2026
No sex drive and my skin hurts all the time like a mild sunburn and it's unpleasant to be touched. 8mg weekly. Worth losing the weight so I deal with it.
BA
Negative
5/31/2025
I just did my second week of 1MG last Sunday and literally don’t feel like I can keep taking it 😩. Depression and just blah. And exhausted. I have lost 7 lbs and don’t have any food noise. I have been getting my protein and fiber in along with electrolytes. I am wanting to lose 15-20 lbs.
TH
Negative
9/8/2025
Yes. Im feeing the same even on 0,5mg and im on week 4. yesterday was my fourth jab. Feel like shit today. Anxiety, little chest pain, face burning up. So Im gonna try to split the dose next week. If this doesn’t help, Im gonna quit Reta.
PH
Positive
2/8/2026
Yeah. I did 0.5mg first pin and felt the appetite suppression the next day. About 16-18 hours in.
AR
Positive
2/8/2026
I started at 0.5mg and did not feel anything. A week later I did 1mg and felt nothing. The third week I did 1mg again and finally started to feel some appetite suppression and got full really fast. That's also the first week I actually lost any weight.
RO
Positive
2/8/2026
I started on 1mg. I felt the appetite suppression the next day. It was too strong but i definitely felt it. I wasn’t hungry at all but I forced myself to eat.
OU
Mixed
2/8/2026
I did my first pin on Thursday this week, and felt the appetite suppression right away. In my case I was really nauseous, and that was the main cause for not eating. Didn’t feel any hunger though, I was only nauseous and then forced myself to eat.
[D
Positive
2/8/2026
I started with .5MG the next day and since had no hunger issues actually went most day without thinking of eating and had to tell myself to eat. Stayed there 2 weeks moved to 1MG last 4 weeks no hunger issues best thing no side effects.. So far lost 10lbs and roughly 1.5% Bodyfat.. Recently moved to 1.5
AN
Positive
3/2/2026
First Week! Progress and Concerns so far. Hey all, I see so many people asking questions early on, so adding my first week experience to hopefully provide input to someone searching in the future. 27M Starting Weight: 273.5 lbs Height: 6'1" Last Measured Weight yesterday: 271 lbs First shot was 5 days ago; 1mg. Felt some effects day one, been keeping my protein intake high, around 150mg of protein per day, though not as high as some people suggest. Tracking calories well, need to get my fiber intake up a bit tho. Biggest Concern: Appetite suppression/food noise was nonexistent for days 1-3. By the end of day 4, I had some of the craziest cravings/food noise I have ever had, gave into some of them. Like I haven't had an issue eating like that in years. Really weird. Calorie deficit for the day was lost that night, still well under...
PA
Positive
7/16/2025
First week done! Just shy of 2kg down ✅
Minimal side effects, feeling lean and energetic so far!
(First 2 pics are today, last two are 8th July 25)
IT
Positive
1/18/2026
I am 60yo woman. I started Reta in one of the studies, Aug, 2024. Exhausted. At my wits end. Obese since age 7. The family embarrassment. Bullied, most fat kids into adulthood know the drill. Had, and still have a very good career, and have always been active. I've tried every tried every diet under the sun. Lost and regained dozens of times. It wasn't laziness, lack of motivation, or anything close to that. I was at 339 pounds, on four BP meds, on a CPAP, not on a cholesterol med, even though my cholesterol was 370. My PCP refused my request for Ozempic. At the end of the double blind study, I was 265. I am buying gray, and now at 176, on no BP meds, no CPAP, my cholesterol is 199. I am tapering my dose down, slowly, to let my skin catch up to the rest of...
DO
Positive
1/31/2026
I've been studying reta for a while and I finally made the leap. My grandfather is a endocrinologist at Hopkins University. He's been going over it with me and agreed it's all good. I have major medical conditions like a rare blood disorder, an autoimmune anemia disorder, lupus , pots and m. Gravis . So trust me when I say I took it seriously because im already so sick. Today I woke up and for the first time my glucose was 78. . In 40 years it's never been under 100. I was shocked. Go for it.
CO
Positive
1/18/2026
PCOS sufferer here. Post menopausal now but it (PCOS) still affects insulin resistance amongst other things. I lost 21lbs on Munjaro stopped (cost reasons) Started Ret 6 weeks ago only small weight loss so far which is to be expected this early and I specially with PCOS. I feel so well on it. Blood sugars are fab all bloods are absolutely normal. I feel the long term benefits ( improved cardio vascular inc dementia, possible future diabetes, inflammatory disease risks etc) for me at my age far outweigh the unknowns. Good Luck with whatever you decide.
TY
Positive
1/18/2026
If I were you Id wait to 10 to 15 years and remain unhealthy because being unhealthy is "safer " than fixing whats wrong now with a PEPTIDE that has been mostly all positive. But Im not you, im me and have reduced my a1c from 5.6 to 5.0. Weight down 40 pounds, all since Mid Sept. Ill take health over worrying about what's gonna happen 15 years down the line. IF your health doesn't deteriate more by then. But to each their own.
TO
Positive
3/25/2026
1st time GLP user. F, 53yo, lifetime exerciser, very healthy diet (I just ate too much) 5’9”, SW 175, CW 150, GW 140 “ish”. .25 first week, no nausea or GI issues at all, maybe a tiny bit of appetite suppression, did nothing for food noise / satiety. Went to .50 / week for the next 8 weeks and immediately started losing approx 1-1.5lbs per week while in a modest deficit (I did not want to lose too quickly) allowing me to eat enough to maintain my normal workouts. Food noise ceased for the 1st time in my life and I was satisfied/ felt full from normal portions. I think actual “hunger” is not as much of a problem for me as “food noise” and satiety. Went to 1mg / week split into 2 pins for next 4 weeks. Upped again to 1.5 mg every 5 days. Currently maintaining 150...
RE
Positive
12/26/2025
I’ve had addiction issues since my teens. By around 6mg weekly of reta, I have lost that constant aching desire. This could really turn things around for so many people with debilitating issues.
NO
Positive
12/26/2025
People forget that GLP-1S weren't even originally designed for weight loss. They were designed to control insulin resistance (IR) and weight loss is a side effect of that.
Another side effect is appetite suppression, which helps a lot of people even if they don't have IR. Non-diabetics can also develop IR.
I'm a T1 diabetic which means I take all my insulin externally. But I also have severe insulin resistance.
On 12mg/week of reta, I'm able to reduce my fast-acting insulin by 95% and my long-acting by 50%. That was also true on 10mg/week of tirzepatide. I've also been able to lower my A1c because my diabetes is so much easier to control.
The best part of GLP-1S was finally being able to lose significant weight and keep it off. But the massive insulin reduction and better A1c is also a HUGE benefit for me, that runs a close second.
JA
Positive
1/22/2026
I’m on week three of my first “cycle” of Reta at a low dose after bulking and cutting for a few years the old fashioned way. My weight is dropping off a lot faster than any other cut, and my lifts are staying more consistent than years past. My biggest problem with cutting is food noise, I’m not sure if it’s because I’m still early in the cut and am anal about meals and timing, but I barely ever think about food now.
JE
Positive
3/25/2026
I started Sept 15th at 0.5mg twice a week for my first week, then 1mg twice a week for my second week, then stuck with 2mg weekly after week 3 and titrated up as I saw fit from there (staying on the same dose for at least 4 weeks before moving up).
Personally i felt very tired and lethargic for the first 4-6 weeks and I wasn’t sleeping well. Now I feel fine! I didn’t have any nausea really, maybe a couple times but only slightly. I did get this weird feeling like I needed to burp but nothing came out which I still get sometimes.
I haven’t come off of it and don’t plan to, so I can’t answer that last question, but anyone will rebound and gain weight back if they fall back into old habits.
EL
Positive
3/25/2026
I started at 1mg for 2 weeks and felt absolutely nothing, good or bad. Jumped to 2.5 and noticed a noticeable lowered appetite. I’ve stayed there for 2 weeks so far. Seems good. Was on low carb before starting trying to hit 150 grams of protein minimum. Some days now that’s a struggle. Only had 2 eggs for breakfast today and took about 5-10 minutes to get it down. That’s usually a minute for me.
FR
Mixed
3/25/2026
I started reta (as my first and only GLP-1) at 2mg/week and I wish I had started lower. I had every side-effect in the book, lethargy, skin sensitivity, nausea, diarrhea... thankfully not all at the same time but still, it was rough. Things eventually got better and reta has helped me lose 45lbs in 4-5 months (way too fast honestly), but if I could go back and start over I would start at 0.5 or 1mg/week to hopefully avoid some of the side effects.
Not sure if my experience has anything to do with not having insulin issues or the diet I was on (low carb high protein), from reading up on reta it feels like the side effects might hit you regardless. There are some side-effect triggers like eating fried/ fatty foods it seems, but I haven't read much about insulin resistance.
KK
Positive
3/25/2026
not obese, no eating disorder, did intermediate fasting and workout to be in shape.
started at 0.5mg a week, Could feel something was going on with my body but no sickening side effects.
Having already healthy habits 0.5mg was enough to reduce hunger and start loosing weight. Gradually titrated up +0.25mg every week. Up to 2mg, but I think it's too much for me now that i've reached my goal i'll try maintenance at 1mg a week.
Effects Overview
Side effects and benefits reported by users
Weight Management
The Weight Management category encompasses user reports related to changes in body weight and appetite control. Users frequently mention significant weight loss and appetite suppression as key benefits. Common examples include reduced appetite and minimal appetite, indicating a decrease in food intake. This category highlights the effectiveness of retatrutide in aiding weight management.
Examples: weight loss, appetite suppression
52%
reported
Health Improvements
The Health Improvements category reflects user experiences related to overall health enhancements. Users often report improved health markers, including better cholesterol levels and regulated blood sugar. Key examples include lowered blood pressure and reduced A1C, showcasing the medication's impact on metabolic health. This category emphasizes the potential long-term health benefits associated with retatrutide.
Examples: improved health, lowered blood pressure
21%
reported
Energy and Motivation
The Energy and Motivation category captures user feedback on enhanced vitality and drive. Many users report increased energy levels and a boost in motivation to engage in physical activities. Examples like energy boost and improved energy highlight the medication's role in revitalizing users' daily lives. This category underscores the positive influence of retatrutide on energy and motivation.
Examples: increased energy, motivation to work out
17%
reported
Mental and Emotional Well-being
The Mental and Emotional Well-being category encompasses user reports on psychological and emotional health. Users frequently mention a confidence boost and improved therapy application as significant benefits. Key examples include increased confidence and feeling good, indicating a positive shift in mental state. This category highlights the potential of retatrutide to enhance emotional resilience and well-being.
Examples: confidence boost, improved therapy application
14%
reported
Cravings Reduction
The Cravings Reduction category focuses on user experiences related to diminished urges and desires. Many users report reduced cravings for various substances, including alcohol and food. Examples like decreased desire to drink and reduced hunger illustrate the medication's effectiveness in curbing addictive behaviors. This category emphasizes the role of retatrutide in promoting healthier choices.
Examples: reduced cravings, reduced addiction cravings
10%
reported
Physical Recovery
The Physical Recovery category highlights user reports on bodily recovery and improvement. Users often mention recovery from various conditions, including hair recovery and reduced inflammation. Key examples include improved gym performance and reduced GERD symptoms, showcasing the medication's impact on physical health. This category underscores the potential of retatrutide in facilitating recovery and enhancing physical well-being.
Examples: recovery, hair recovery
9%
reported
Quality of Life
The Quality of Life category encompasses user feedback on overall life satisfaction and well-being. Users frequently report a better quality of life and positive lifestyle changes. Examples like improved biomarkers and improved well-being highlight the medication's broader impact on daily living. This category emphasizes the potential of retatrutide to enhance overall life quality.
Examples: better quality of life, quality of life
9%
reported