Effectiveness
Users report improvement78%
Side Effects
Reported side effects28%
Would Recommend
To others with same condition77%
Avg. Duration
Average reported usage duration3-6 months
Side Effects Frequency
Percentage of users reporting each side effect
Sentiment Analysis
User sentiment from reviews and feedback
Positive
65%Neutral / Mixed
15%Negative
19%Featured User Reviews
Recent experiences from users
GL
Positive
2/14/2026
Great peptide. Been doing for about a year. Labs all good. Great for skin and hair and just generally looking and feeling young. I take breaks - but def recommend. Listen to your body and adjust if needed.
HU
Negative
8/11/2025
2 mg 2 times a week gave me the worst headaches and nausea, start low and build up
NA
Positive
3/14/2026
I've pinned it for 3 months everyday. Results are great. Even pinning my skin is definitely harder. Hair is definitely thicker. I'm preparing to cycle off pinning and making my own serum with GHK and Snap for about a month. Then I'll cycle back on pinning.
TY
Positive
3/14/2026
I never got the “skin purge” that people talk about - acne and worse skin before it cleans up - but the healthy looking face came in at about week 3, crows feet kind of filled in, reducing fine wrinkles. I am at 8 weeks now
JE
Positive
3/17/2026
5 weeks in on GHK-CU and my bald spot started to fill in, my hair got darker, and skin was looking better. It depends on the person.
IT
Positive
1/27/2026
I started using then two months ago 2mg a day amazing results my skin glows n it even reflects light now lol and im having new hair growth around my hairline then my wife saw the changes she has hyperpigmentation dark circles and few other issues shes been using it to for around 4 weeks now its 2mg aswell her hyperpigmentation is gone on left side and right side about 85 percent gone dark circles gone aswell skin is more clear and my skin is like next level but my diet is really clean aswell i complete all vitamins minerals everyday drink 3-4 liters of water take ZMA vitamin e c vitamin D and vitamin B and i have a full weekly skincare routine with copper peptide and retinol vitamin c n few other things planned different on each day of the week. I can share my skin care routine...
LO
Positive
4/10/2026
I’ve been on 5mg daily for four months now, with one three week break in between. I started at 1.5, then moved to 2 based on Anela. At 2 I was noticing some effect but not enough. Went to four, then eventually 5. Take a zinc supplement. Skin is beautiful, soft and glowing. Even my stretch marks are GONE!
MR
Positive
3/16/2026
Takes about 6 weeks to start seeing improvements for many. I started noticing fine lines in my forehead were going away and my turkey neck from weight loss of over 190LBS is going away as well. Stuff works like magic! I've been on it for 4 month's now and people tell me I loook 5 years younger already. My hair and nails are growing really fast as well.
DU
Positive
3/14/2026
Im 5 weeks in and my scalp eczema has gone completely and for the first time in years i have nothing anywhere else either - feel pretty annoyed that i didnt know about this earlier as have spent years having docs throw topical steroids at me im 51f 🙏🙏 i will be forever grateful for finding myself down the peptide rabbit hole 😍
SE
Positive
3/14/2026
I've been on and off it for quite some time. Problem is I take other peptides that have either a direct impact on your skin. I use or have used these in conjunction with GHK-Cu: BPC-157 → healing and repair KPV → anti-inflammatory skin support Epitalon → longevity / anti-aging signaling TB-500 → deeper tissue repair Obviously, three of these are commonly found in the KLOW blend. That said, GHK-Cu has been shown in gene expression research to activate or suppress over 4,000 human genes, many related to skin regeneration and collagen synthesis. That’s one reason it’s considered one of the most powerful peptides for skin quality. In my personal experience, GHK-Cu has had a pretty noticeable impact on my hair and skin quality. Obviously everyone is different, but it’s one of the compounds where I’ve actually seen visible changes. This definitely has not happened overnight. There is also NAD⁺...
LE
Positive
4/12/2026
I did 9 weeks of KLOW first, where the ghkcu was 2-2.5mg nightly. Then I took a week break and started ghkcu on its own. I did 5 weeks of 3.33mg nightly.
The picture shows the before and after for the KLOW protocol. The biggest improvements were reduction in redness, way thicker skin (especially around the eyes), and overall skin softness and smoothness. My hair also improved in that it is no longer oily. I’m hoping with continued use, I’ll see more hair benefits.
I took a 3 week break after the 5 weeks and now am just dosing 2mg a night so the vials last longer. I’m loving the results and will continue to incorporate ghkcu in my routine.
https://preview.redd.it/gtwmlsuqrnug1.jpeg?width=2048&format=pjpg&auto=webp&s=ac2ca8d21c01285adb4d11806d12a1705f4b34d6
NA
Positive
4/11/2026
I’ve been on it for 3 months. I started seeing results (more plump, smooth, less red, and tighter skin) after about a month and I really feel it’s getting better by the day. My face used to get dry and red easily and now I don’t use as much moisturizer and redness completely gone. My hands got really dry and now they’re baby soft it’s insane. And just firmer skin overall specifically on thighs.
I use it daily 2mg (needle fatigue is real keep that in mind) (a 50mg vial with 3ml bac water added which is 12 units a day) sometimes the injection can sting but nothing too bad at least for me. It helps to warm it up in hands before hand for like 30sec
I plan to take a month break after 6 months.
BR
Positive
4/11/2026
I’m about 6 weeks into GHKCU. I take 2mg day. It was a month before I noticed anything and it was slight. Now I’m starting to see much more noticeable improvement. I’m 49 and my skin is looking younger and better. It’s not a miracle…. But it’s a noticeable difference.
VA
Negative
4/11/2026
I used it topically as a “skin remodeling” agent. After 4-5 months I developed a sensitivity to it and stopped using it. In retrospect I didn’t need any skin remodeling in the first place.
EM
Positive
4/12/2026
I have psoriasis flares in some spots and since I started GHK, it has not made a return at all. Weird but a good thing.
AG
Positive
4/12/2026
Used it for 12 weeks , had acne scars , 1/4 of them gone, overall felt good, felt less inflamed and more clear minded (only little side effect ) - bit of diarrhea and pain while injecting
UN
Positive
4/12/2026
I’ve been using 2mg 5 night a week for about 3 months now. Along with micro needling and good skincare, my skin has never looked better. I’m 42 and most people think I’m much younger. No Botox or filler and not a wrinkle in sight! And I rarely need any makeup which is a bonus. Redness has gone down and skin tone and clarity have improved.
My hair hasn’t changed much but I don’t think I’ve been on it long enough to notice that. So far I am happy with it and will continue as I’ve heard using it 8-9 months is what the real changes happen.
WI
Positive
4/12/2026
I’ve been running if about 7 weeks now and noticed such a difference in hair growth and my skins so glowy
SH
Positive
4/11/2026
Took me about 2 months to start noticing stuff. Was taking 2mg daily. My hair is completely different, its nice thick and soft now. My skin was already flawless so didnt notice anything their, but the hair change is what i was hoping for since i used to have thin hair. Went from being thin and frizzy to soft and lush
LA
Negative
4/11/2026
im doing it topical, cant tolerate when injected as it makes me feel out of touch/ reality, brain fog.
CH
Positive
10/4/2024
I have about four weeks experience with the Anela Protocol (topical/subq) and all I can say is DoctordUp should get a Congressional Metal of Honor or something! Follow instructions to avoid the sting. I saw big results the first week (60 yr old, lost c.45#s), and by week three I was canceling my four-figure cosmetic surgeon quarterly appointment. Pro Tip: Take a zinc supplement so you don’t need to worry about too much copper building up in your system. Do as she says, it is SO worth it!
[D
Positive
10/3/2024
3rd degree burn on my forearm from the edge of a very hot cast iron pan. Almost seemed to heal right before my eyes, the huge burn blister immediately responded and became smaller, within one week it was healed and there is no scar now. GHK-CU cream. I now make sure to always keep some on hand. I tried it as I did not have burn cream and remembered how it can help heal and help your skin and I was happily amazed and relieved. N-1 incident but i am a believer in this stuff now.
CI
Positive
12/2/2024
I started ghk-cu sub q injections and it's getting red and painful sometimes, thanks for the advice I'll try massaging the site after! Other than that I've been using red and near infrared LED lights along with copper peptides topically and methylene blue and getting fantastic results on my skin. I'm 50 and the lines on my face are gone now. I did epithalion as well, excited to see what ghk-cu does for me!
NE
Negative
1/20/2025
For anyone interested, I injected Ghk cu in my thigh last night, trying to give my stomach a break, and still in pain 20 hours later. I inject with BPC 157, and it always hurts a little afterwards, but NOTHING like this. Everyone is different, but wanted to put this out there in case someone else had this experience, or knows why this would happen
HO
Positive
3/11/2026
I’ll say that I saw a rejuvenation and tightening of my skin after around the 10 to 12 week mark.
I have lost a considerable amount weight and do believe that it helped a lot with any lasting issues from that.
Also, my nails have been growing crazy fast too. Especially my toenails strangely enough.
TA
Positive
3/11/2026
i personally really like it. normally i get horribly dry skin in the winter, but run it for about 6 weeks this winter and my skin has been great
[https://peptidewiki.co/guides/dosage-guides/ghk-cu-dosage-guide](https://peptidewiki.co/guides/dosage-guides/ghk-cu-dosage-guide) has a good guide
RA
Positive
12/17/2025
I’ve been on 4mg of GHK-CU for about 3 weeks and my acne has gotten a bit better (but is it still noticeably there).
If the root cause is hormonal, you aren’t going to fix it this way. If it’s a skin inflammation/irritation problem you have a better chance this peptide will benefit you.
CH
Positive
4/6/2026
I currently am beginning GHK-Cu at 1mg subq injection. So far I’ve only noticed my hair is growing a bit faster. I can tell by looking at my roots. That’s the only difference I’ve noticed so far. I’ve only been on it around a week.
GU
Negative
12/21/2025
I had to stop using ghkcu because even when following the Anela protocol I had massive welts that would bruise and cause the entire limb to ache, I wish I could’ve continued but the pain was so bad I couldn’t sleep
ER
Positive
12/22/2025
I let my GHK CU out of the fridge for 20 minutes prior to pin. It has reduced the sting to zero
WI
Negative
12/22/2025
I’ve been “fighting” this the last 2 weeks (week 3-4 on GHK). Larger, nickel size, itchy welts on my neckline and small rashes on my forearms that come and go. I recently changed soaps/shampoo and started Finasteride (1 month in) so trying to pin point the reaction reason. I also thought Tesa was the culprit but I was halfway through the cycle and stopped to see if IT was the reason. I’m mixing GHK w/BPC daily and Reta weekly but it seems GHK is the real reason. I may take a break from the GHK and finish the Tesa since it was working well.
DA
Negative
12/22/2025
I am doing 1mg a day reconstituded 2.5mg of bac water and pin 5units daily. I got the itching the first dose I took and rash everywhere 3 hours prior. Haven't had the experience since.
KN
Positive
12/24/2025
Had the itchiness and hives my first time. Took antihistamine. Was fine day and half latet. Havent had those issues since to the point i dont have to take antihistamines with GHK-CU now
MR
Negative
12/26/2025
Side effects of ghk-cu
So i have been using ghk-cu for 2 weeks now. Today was the first time I used a syringe for a second time and now I have a bruise on the injection site. When I put my finger on it it’s hard and hurts a little. Normal ?
IL
Negative
12/31/2025
I cannot and will not do GHK in the abdomen, I felt like I had a hernia. I’m not smart enough to stop at once or twice, probably did the abdomen six times. Glutes only for me.
MO
Positive
12/31/2025
It’s normal from my experience. It never hurts to do the pin, but up to a few hours after I typically have a spicy feeling around the injection site, internally. To help with that, I pull more bac water in the noodle with the GHK-cu (not the vial) and let it warm to room temp beforehand. It helps a lot.
NO
Negative
12/31/2025
Same thing happened to me. No sting when injecting. I thought the coast was clear, then about 3-4 hrs later the pain started. I felt like I’d been punched in the stomach. I also have red welts that look like cigar burns. I’ll never use GHK-CU in the stomach again. I’m wondering if the body can get use to micro doses, and then slowly up the dose?
RE
Negative
12/31/2025
Good advice to not do in abdomen I lightweight feel like it’s making scar tissue and my tummy hard where I’m injecting
RA
Negative
12/31/2025
Ghk-cu hurts anywhere. Part of its thing. The bpc157 helps the pain . It’s the only way to go. Always take them together or it hurts too much
LO
Negative
12/31/2025
I only inject ghk-cu and the the other copper peptides on a chunk of fat from my butt - it’s way better and with little to no sting. I did an injection of ghk on my abdomen yesterday and immediately regretted it. Spicy vibes ~
AV
Positive
12/31/2025
I inject 15mg every 5 days, and don't feel anything but slight burning.
DU
Positive
1/1/2026
I kept giving injection in the same area of both upper glutes, not the same exact spot but near. I ended up with fat atrophy, but it was the only area that didn’t hurt like crazy. I had thought at first the blue had just dyed my skin. I had great results while on it.
CU
Negative
1/2/2026
I’ve used ghk-cu with the Wolverine 4 times now. 3 in glute and one in abdomen. The pain from ghk-cu is becoming unbearable and lingers for over 24 hours. It’s sharp pain and the area stays bright red. Ugh. I might just stop ghkcu all together….
GU
Negative
12/21/2025
I had to stop using ghkcu because even when following the Anela protocol I had massive welts that would bruise and cause the entire limb to ache, I wish I could’ve continued but the pain was so bad I couldn’t sleep
ER
Positive
12/22/2025
I let my GHK CU out of the fridge for 20 minutes prior to pin. It has reduced the sting to zero
RO
Positive
2/11/2026
I started low as I do with any peptide to see how my body reacts. I dose 1.5mg every other day now, I’ve only been on it a month and my face is absolutely looking more plumper and clear. I’ll stay on it until my vile runs out. Prob 2,3 months then take a break and cycle back on.
JO
Mixed
2/12/2026
I’ve been taking it for a month now. My first dose made my heart rate spike and I got pretty nauseous. I do a KLOW blend and I find that it helps if I eat before I pin it.
RE
Positive
3/14/2026
From my reading and research this is what i understand. You shouldnt expect to start to see improvements (in regards to skin texture/ageing etc) until around week 6 and even then it will most likely be minimal. Its weeks 6-12 that things should really start to kick in to gear. And then realistically you probably want a good 6 months on it to see the full results. Im on about week 5. I am suspecting that i am getting the “copper uglies” on my neck as it looks super crepey its weird, never been like that before. But apparently its the collagen remodeling. That being said, i have always had thin, brittle, weak nails that take long time to grow. Well from about week 2 my nails have been strong and healthy and now at week 5 they are the longest, strongest, thickest they have ever been. But apparently the...
DA
Positive
3/14/2026
I’ve use GHKU-cu SubQ for the past 8 days now.
I saw result within the first 1-2 days on my skin quality and some old scars started healing. Seeing progress on this every single day. Even my partner for 15 years clearly sees the difference
TR
Positive
3/14/2026
6 weeks in... What i have noticed is better skin, cant explain but my hair feels fuller and silkier "lol" i ve heard you can use it year round but not sure will go by how i feel.
TE
Positive
3/14/2026
I’m a month in and noticing decreases in wrinkles. Not giant but noticeable differences. Also, I have had chronic cracked heels for literally decades. I have definitely noticed a decrease there in the severity and depth of the cracking. This is not why I was taking it but happy with that for sure.
SL
Positive
3/14/2026
One month on ghkcu and my lab rat has much smoother thicker skin, seems a little tighter and a black spot on his lip is gone. 2nd month added kpv for 2nd month and all acne is gone
RU
Negative
3/14/2026
I have used it for two 8 week cycles but I think the 1-2 mg dose might have been to much. At the end of the last one I had consistent small blemishes in random places. Next one I’m might try .5
I’m not sure how much difference I notice in general though.
EL
Positive
3/14/2026
After 4 weeks my sagging skin from weight loss is noticeably better. Have noticed the crepey skin on my arms and neck are marginally better. 2-2.5 mg subQ per day and topically in areas as I remember or have time for (habitually late to things so sometimes it doesn’t happen)
PO
Positive
3/14/2026
5 weeks in and starting to see a difference.
Can tell it's working since my nails are growing much faster than usual. Skin feels tighter as well. Going to run it for 16 weeks.
CE
Positive
3/14/2026
Took a solid 5 months before noticing anything.
And I was dosing 3mg
Skin improvement. Yes
Hair no
NA
Positive
3/14/2026
I've pinned it for 3 months everyday. Results are great. Even pinning my skin is definitely harder. Hair is definitely thicker. I'm preparing to cycle off pinning and making my own serum with GHK and Snap for about a month. Then I'll cycle back on pinning.
TY
Positive
3/14/2026
I never got the “skin purge” that people talk about - acne and worse skin before it cleans up - but the healthy looking face came in at about week 3, crows feet kind of filled in, reducing fine wrinkles. I am at 8 weeks now
JE
Positive
3/17/2026
5 weeks in on GHK-CU and my bald spot started to fill in, my hair got darker, and skin was looking better. It depends on the person.
LU
Positive
10/15/2025
You can start low. I see no problem.
I started with 0,5mg and went up to about 1mg per day. Thats my sweet spot.
I feel it working on my skin and I have no side effects like on higher doses.
There is no must, that you use 2 mg or more per day. everyone is different.
TR
Positive
8/4/2025
I’ve completed one cycle and half way through the second.
I buy 50mg vials also. Since this peptide can cause a histamine reaction around the injection site, which can be slightly painful for a day or two, I try to make it as dilute as possible. So, I reconstitute with 3mL of BAC water. That gives me a concentration of 16.667mg/mL. At that concentration, every 10 units (0.1mL) delivers 1.667mg. 12 units = 2.0mg.
I take 2mg/day, 7 days a week, for 6 weeks. Then I take a 2-3 week break. Rinse, repeat. During the 6 weeks on, I also take a 25mg zinc supplement. I’ve noticed a substantial improvement in skin quality. It’s thicker and smoother. I was hoping that it would help with my thinning hair, but I haven’t noticed much change there.
10mg/day sounds *way* too much.
QU
Positive
4/12/2026
I’m 27 not a young adult but I have had great results with Ghkcu for acne scars and improving skin texture. I also have really bad cystic acne for the last 10 years and nothing has helped. I’ve been using for the past 4 months and it’s already helped so much I haven’t had any breakouts.
DO
Positive
2/23/2026
I’ve noticed my white hairs reverting to black on my head and face. Also within a couple weeks, my skin looks smoother and feels tighter. Head hair regrowth has also happened to a high degree. I use a few other interventions though so hard to attribute that to the ghk.
MU
Positive
2/22/2026
Have heard about the “copper purge”, but first let me ask if you are 100% certain you got high quality GHK-CU. I’ve taken it for 2 weeks and just in the last 1-2 days noticing the skin smoothening - visibly looking in mirror and feeling my face. Also when pinning, the skin being tougher to penetrate with needle - started seeing this within the first 3-4 days.
NO
Positive
2/22/2026
im on Accutane and ghk-cu and one things for sure sure it 10000% helps heal scars faster and pimples its amazing
GO
Positive
2/23/2026
I've been pinning 5mg daily of only ghk-cu for about a month now, and I've definitely seen improvements. I'm a 54 yo male, btw. Hair is filling back in. Crepey skin is looking tighter and smoother. My only complaint is the increased facial acne. From my research, that will go away eventually. I'm quite pleased with my results. I have ten 100mg vials, so I'm stocked up for the long haul. No plans to cycle off of this one.
LA
Negative
2/22/2026
i tried it few times pinning but it gives me brain fog, but i will re-challenge again next week. meanwhile it's been 1 month on topical already, it somehow grows tiny teeny vellus hairs but never goes longer than a centimeter lol
MK
Positive
2/23/2026
Purging not quite I been feeling greate skin is more plum more younger in away I’d say cuz of elasticity of skin and less fine line on my forehead still there but tiny bit less than before I noticed but otherwise no purging no ugly copper
LI
Positive
2/24/2026
My hair is growing so much!! I’ve got all these baby hairs that I thought were frizz but nope it’s new hair growth. I started taking this for my skin, and was SHOCKED when it also started healing my gut!! I also stopped the Botox. This is a miracle peptide I’m gonna get my mom on it.
ON
Positive
2/26/2026
I've been on it for about 4 months at 2mg/day.
I did hit a point where I started losing my hair - the pattern did not follow MPB and this did cause me some stress, but I realized it was causing a new growth phase. hair is filling out and is growing well. Skin looks amazing. I've been running the KLOW stack - as I had surgery and was using the combo to help with recovery and scarring - along with the other benefits. I'll be switching to just GHK-Cu once my latest bottle of KLOW is complete
AU
Positive
2/26/2026
About 4 weeks. My hair has improved. A little softer compared to w/o ghkcu. Less flakes on my scalp too.
For the skin, bumps on my face started to become smaller. Sometimes I would run my nails on the bumps and whitehead will come out pretty quick. Like, as if they were just out there hanging waiting to be wiped off. Pimple dries fast.
I haven't noticed about the white hair because mine was dyed before I got on to this wonderful peptide.
PA
Mixed
3/7/2026
Hey man, so i basically started 2 days ago and also had many questions about it and did my research. I started ghk cu because of my pimple scars and overall skin and also the anti inflammatory benefits that could support my arthritis. As you could guess there arent really any noticable results after just 2 days.. maybe some red spots in my face that slowly started to fade away but that could also just be placebo. I store mine in my fridge (ideal temp should be 2-8 degrees celsius) and i only take it out for injecting. I started pinning in my stomach and it does not hurt that bad tbh, its just like a little sting that lasts for about 20 minutes. After a few hours it may itch a little and redness starts to fade away. If you are unlucky it might build up some type of...
EW
Positive
1/19/2026
I unintentionally cured a tooth infection with GHK-Cu. It’s pretty funny. I was doing a course of it to see if it had any of the vaunted skin effects (I’m a 52 year old woman). I had had a toothache and it was getting in my jaw for about a week at the point when I started it, and was kind of delaying going to the dentists for who knows why. Anyway, a few days into the GHK-Cu, the tooth got better. Or rather the pain got better. All I could think was that the extra copper had an antibacterial effect.\
Eventually the toothache returned and I had to go get a filling. I wouldn’t really recommend doing what I did, but I did find it amusing. It was like a short course of antibiotics.
WI
Positive
12/5/2025
Copper peptides are amazing, but they are very unstable. I use the Blue Biotic from Parallel health .io, recommended by my derm, which not only has a high dose of GHK-Cu (copper peptides), but also other peptides like snap 8 and matrixl3000 that help with reducing wrinkles and building volume. I use it every day morning and night and now only do botox once a year instead of four times a year because I just don’t need it as often.
PR
Positive
12/5/2025
I use Allies of Skin copper peptides. It saved my skin barrier which was highly damaged. The skin around my cheeks and nose had turned into sandpaper after I gave birth and using copper peptides helped repair things.
UN
Positive
12/5/2025
They help with healing and collagen building, and they wake your face up a bit—makes it look a bit more perky and bouncy. I experienced benefits right away. I didn’t even know what they what they were , but I noticed a change in my skin, so I looked them up and learned more about them. They also seem to make my face feel slightly thicker for lack of better terms.
EL
Positive
3/14/2026
After 4 weeks my sagging skin from weight loss is noticeably better. Have noticed the crepey skin on my arms and neck are marginally better. 2-2.5 mg subQ per day and topically in areas as I remember or have time for (habitually late to things so sometimes it doesn’t happen)
PO
Positive
3/14/2026
5 weeks in and starting to see a difference.
Can tell it's working since my nails are growing much faster than usual. Skin feels tighter as well. Going to run it for 16 weeks.
CE
Positive
3/14/2026
Took a solid 5 months before noticing anything.
And I was dosing 3mg
Skin improvement. Yes
Hair no
MO
Positive
12/5/2025
Results I got and expected- skin looks bouncier, plumper (not fillers plump, but subtle oomph). Results I got and did not expect - redness reduction that I cannot explain. But the addition of copper peptides was the only change I made at that time. When I add any new product or change product frequency, I always wait 4 weeks before changing anything else because my skin is temperamental. So I can clearly attribute the changes to the peptides. They just make my skin look better.
KA
Positive
12/11/2025
I inject ghk-cu at 2-3mg per day. It’s helped my skin sagging from weight loss, but honestly the primary benefit has been my hair. It’s full and bouncy and no longer thinning. Baby hairs started to grow back in. 🤷🏻♀️ Wasn’t expecting it but I’ll take it.
EY
Negative
11/30/2025
Yeah, this product irritated me so I had to discontinue it. I had to accept the fact that copper peptides and me don’t get along well lol. My skin also can’t tolerate vitamin C, I wonder if there’s a link. But yeah, I would discontinue this if you’re getting a reaction from it.
EM
Mixed
12/3/2025
Late to the party here. I use TO copper peptides BUT I had used it, got a fright and never used it again for a year.
I noticed a somewhat saggy effect, worsening texture, lines appeared more prominent. I went in with it twice a day at first.
It's back in my routine now but I dont use it twice a day, or every day. I use it once every second day and I actually love it now. Maybe before it was just too much copper in one go which I believe can have a paradoxical effect?
I got the same with retinol, however I have never been brave enough to touch that again 😂😂
BR
Mixed
4/26/2023
I’ve tried 4 different ones and my HG is niod cais.
TO Buffet CP did nothing for me. Not saying it’s not good but my 49F skin really needs more.
SubQ Skin made some change.
CAIS is great for me. Have repurchased many times. I started seeing results after 3-4 months I think, after 75% of the large bottle. It gives my mature skin a fresh young glow, and makes it plumper.
CAIL I’m using now, halfway a tube so it’s too early to tell. Don’t want to judge before finishing it.
[D
Positive
5/25/2023
Old post, just wanted to add my own experience. I’ve been using copper peptides since 2006. On and off, but mostly on. I always use the Skin Biology copper peptides, as they’re formulated by the scientist who discovered the anti-aging properties of copper peptides (Dr. Loren Pickart) I tried the NIOD and The Ordinary Buffet + CP when they first came out as I was curious, but went back to Skin Biology to me they’re much stronger. Well actually Skin Biology offers a range of copper peptide strengths, as well as raw copper peptides you can add to your choice of skincare. The product I use the most is the Skin Signals serum, I just love it. 2-3 sprays on my face right after cleansing. I’m 52 and my skin is radiant (not trying to be boastful, but it really is, the copper peptides and AHAs definitely paid off I...
TO
Positive
8/22/2025
I have used Copper peptides for 5 years for my face, neck, chest and scalp in conjunction with my microneedling pen and I love the results. This is a serum I will never stop using. I am 53 and I look 10 to 15 yrs younger.
SY
Positive
12/8/2023
Since using this serum, I notice breakouts heal up so much faster. Typically when I have breakouts they will last for 1-2 weeks. Now they seem to heal up in a matter of 3 - 4 days. Also, I notice the lines underneath my eyes are a lot softer.
ST
Positive
6/25/2024
I have been using copper peptides for 3 years now (currently 31)and it's something I never leave out of my morning routine. I do notice a difference in plumpness and firmness when I use it and how my skin feels without it. You definitely don't have to spend the $$$ to get a good serum (I generally use the ordinarys copper peptide) but I can under if $30-40+ is still expensive for people on a budget. I would say this is definitely worth trying just once to see if it benefits you. The only downside is you can't layer it with a lot of other ingredients so whether you are using it in the morning or night the routine will have to be minimal in order to get the most out of it. Hope this helps.
[D
Positive
7/11/2024
Copper peptide injections seem to be the only real effective and results proven method for me. Took 8 weeks but I see a massive difference not just in my neck but also the skin all over my body.
ZE
Positive
11/29/2025
A week ago I started injecting GHK Cu and took before pics. I’ll take a pic monthly to monitor my progress.
I can say that, the knee soreness (I had since my knee replacement 2 years ago) is gone!!!
GR
Positive
1/12/2026
I’ve used peptides for injury repair etc and tried ghk-cu for a couple cycles (btw you receive it as powder in a vial and have to reconstitute it with bacteriostatic water and inject it. Some ppl not comfortable with that)
I actually think ghk-cu is great and will start a 3rd cycle soon.
I think I get it for like £30 for a months supply
I am atopic too but wasn’t previously having any flares during that so can’t comment for eczema
MI
Positive
12/18/2023
GHK-Cu Copper Peptide Skin Rejuvenation I'm an aging model, a devotee of timeless elegance, and a former professional bodybuilder. I've always been attuned to my body's needs, and recently, I embarked on a rather remarkable journey with a peptide called GHK-Cu. Initially, when I began my 30-day cycle with GHK-Cu, I was taken aback by its striking blue color. "Is this normal?" I pondered. But then, a revelation struck me - copper, a key component of GHK-Cu, naturally exhibits this azure tint. It was a moment of learning and acceptance. The idea of daily injections was daunting at first. After all, who relishes the thought of needles? But as someone who understands the body's complexities, I was intrigued. The commitment paid off – friends and acquaintances began remarking that I looked a decade younger, just after a 30-day cycle of 2mg per day. The results were astonishing! For those curious,...
AL
Positive
3/20/2026
Finally cracked the GHK-Cu sting - here's my pain-free protocol Like most of you, my first GHK-Cu injections felt like getting stung by a bee, with red welts that lasted days. I tried the Anela protocol (icing, slow injection, the whole thing), but even with all those steps it was still uncomfortable and felt overcomplicated. So after trial and error, I landed on a protocol that made my injections **completely painless**. No sting, no redness. Here it is. *Disclaimer: not medical advice. Consult your healthcare provider. This is just what worked for me.* *Edit: updated to reflect a few solid points raised in the comments.* # The "warmpin" protocol (2min) **1. Dilute** Reconstitute with **3 mL of bacteriostatic water per 50 mg vial**. This is the single biggest factor. Most of the sting comes from concentration and osmolality, the more dilute the solution, the gentler it is on tissue. Don't...
EM
Mixed
12/3/2025
Late to the party here. I use TO copper peptides BUT I had used it, got a fright and never used it again for a year.
I noticed a somewhat saggy effect, worsening texture, lines appeared more prominent. I went in with it twice a day at first.
It's back in my routine now but I dont use it twice a day, or every day. I use it once every second day and I actually love it now. Maybe before it was just too much copper in one go which I believe can have a paradoxical effect?
I got the same with retinol, however I have never been brave enough to touch that again 😂😂
SP
Negative
1/22/2026
Just noticed smile lines going from my nose to outer corners of my mouth after using this for a week… I never had those lines before EVER! Was using twice a day and will discontinue now… really hope it goes back to normal - makes me look way older and my skin way looser. So frustrating!
WI
Positive
12/5/2025
Copper peptides are amazing, but they are very unstable. I use the Blue Biotic from Parallel health .io, recommended by my derm, which not only has a high dose of GHK-Cu (copper peptides), but also other peptides like snap 8 and matrixl3000 that help with reducing wrinkles and building volume. I use it every day morning and night and now only do botox once a year instead of four times a year because I just don’t need it as often.
PR
Positive
12/5/2025
I use Allies of Skin copper peptides. It saved my skin barrier which was highly damaged. The skin around my cheeks and nose had turned into sandpaper after I gave birth and using copper peptides helped repair things.
MO
Positive
12/5/2025
Results I got and expected- skin looks bouncier, plumper (not fillers plump, but subtle oomph). Results I got and did not expect - redness reduction that I cannot explain. But the addition of copper peptides was the only change I made at that time. When I add any new product or change product frequency, I always wait 4 weeks before changing anything else because my skin is temperamental. So I can clearly attribute the changes to the peptides. They just make my skin look better.
KA
Positive
12/11/2025
I inject ghk-cu at 2-3mg per day. It’s helped my skin sagging from weight loss, but honestly the primary benefit has been my hair. It’s full and bouncy and no longer thinning. Baby hairs started to grow back in. 🤷🏻♀️ Wasn’t expecting it but I’ll take it.
LO
Negative
12/5/2025
Be careful, I pinned them, 2mg a day and got severe copper uglies and started to look a lot older. If u do too much it actually destroys collagen.
Think topical is the better way, start 3 times per week and look how your skin is reacting.
IM
Positive
6/17/2022
I started using copper peptides recently in place of tret as my partner and i are trying to have a kid, and so far I haven't noticed much of a difference (which is good because the tret was working wonders so I at least haven't backtracked my progress!) My skin feels super smooth and I haven't noticed any loss in firmness or anything, if anything I feel like my crow's feet are slowly beginning to improve. I had only been on tret for a couple of months, so it may be a combo of the two. I simplified my routine recently (all products are The Ordinary unless stated otherwise): AM: Resveratrol 3% + Ferulic Acid 3% Vitamin C 23% suspension Moisturizer Mineral SPF (Vichy) PM: Niacinamide 10% + Zinc 1% (usually every other night as I find it dries me out a bit) “Buffet” + Copper Peptides 1% Moisturizer Slug...
EM
Mixed
12/3/2025
Late to the party here. I use TO copper peptides BUT I had used it, got a fright and never used it again for a year.
I noticed a somewhat saggy effect, worsening texture, lines appeared more prominent. I went in with it twice a day at first.
It's back in my routine now but I dont use it twice a day, or every day. I use it once every second day and I actually love it now. Maybe before it was just too much copper in one go which I believe can have a paradoxical effect?
I got the same with retinol, however I have never been brave enough to touch that again 😂😂
SP
Negative
1/22/2026
Just noticed smile lines going from my nose to outer corners of my mouth after using this for a week… I never had those lines before EVER! Was using twice a day and will discontinue now… really hope it goes back to normal - makes me look way older and my skin way looser. So frustrating!
EN
Mixed
1/3/2026
I've tried GHK-Cu topicals for months, and it slightly worked, but to be honest it wasn't great. I switched over the vial form through NextGenPeps, and ordered the GLOW stack.
I noticed a difference in a matter of weeks rather than constantly reapplying and seeing no results.
Topicals may work for some people, but the vials tend to work effectively for everyone. Just my thoughts.
CR
Positive
9/7/2025
I only use GHK-CU (the copper peptide) subcutaneously. I have cycled on and off with another peptide called BPC-157 for a couple of years now. My skin heals faster, it seems thicker yet softer, and it is definitely more resilient. I don't use copper peptides topically because it doesn't play well on my skin with Tretinoin. I am also a fan of red light therapy. Have a mask and panel. Also drink collagen peptide powder. As long as you are consistent with applying peptides 2x's a day, you will see results. I use Snap-8 and other peptides topically. Snap is the secret weapon, however, and lasts about 12 hours. Some others that come to mind in my products are hexapeptide-12, Matrixyl 3000, and Arginine polypeptide. Those I've been using on and off for years; but consistently for the last 2, I think. Maybe 3. For reference: I will be 49...
IM
Positive
6/17/2022
I started using copper peptides recently in place of tret as my partner and i are trying to have a kid, and so far I haven't noticed much of a difference (which is good because the tret was working wonders so I at least haven't backtracked my progress!) My skin feels super smooth and I haven't noticed any loss in firmness or anything, if anything I feel like my crow's feet are slowly beginning to improve. I had only been on tret for a couple of months, so it may be a combo of the two. I simplified my routine recently (all products are The Ordinary unless stated otherwise): AM: Resveratrol 3% + Ferulic Acid 3% Vitamin C 23% suspension Moisturizer Mineral SPF (Vichy) PM: Niacinamide 10% + Zinc 1% (usually every other night as I find it dries me out a bit) “Buffet” + Copper Peptides 1% Moisturizer Slug...
CR
Positive
8/9/2022
Ive had solid results from copper peptides. I try to isolate them and use other peptides/ keep it simple (i know l ascorbic acid is no good with them, but wondering on vitamin c derivatives +vit c rich plant extracts/oils? Or antioxidants like resveratrol?)
I LOVED the Lovinah copper peptide ampuole. Its expensive but i saw dramatic improvement especially around my eyes- seemed like it plumped a lot of lines and kind of brightened. I use their peptide night mask afterwards and that combo has been amazing especially for redness or blotchiness.
Im using the CAIS serum and really liking it a lot! Using the klairs midnight blue growth factor serum as well, and finishing with that lovinah mask. The ordinary buffet copper peptides are fine but i honestly didnt get any results (fine product though- i like their matryxl or argieilene more).
EN
Mixed
1/3/2026
I've tried GHK-Cu topicals for months, and it slightly worked, but to be honest it wasn't great. I switched over the vial form through NextGenPeps, and ordered the GLOW stack.
I noticed a difference in a matter of weeks rather than constantly reapplying and seeing no results.
Topicals may work for some people, but the vials tend to work effectively for everyone. Just my thoughts.
MI
Positive
12/18/2023
GHK-Cu Copper Peptide Skin Rejuvenation I'm an aging model, a devotee of timeless elegance, and a former professional bodybuilder. I've always been attuned to my body's needs, and recently, I embarked on a rather remarkable journey with a peptide called GHK-Cu. Initially, when I began my 30-day cycle with GHK-Cu, I was taken aback by its striking blue color. "Is this normal?" I pondered. But then, a revelation struck me - copper, a key component of GHK-Cu, naturally exhibits this azure tint. It was a moment of learning and acceptance. The idea of daily injections was daunting at first. After all, who relishes the thought of needles? But as someone who understands the body's complexities, I was intrigued. The commitment paid off – friends and acquaintances began remarking that I looked a decade younger, just after a 30-day cycle of 2mg per day. The results were astonishing! For those curious,...
HO
Mixed
11/23/2025
I bought it 5 weeks ago and used it as the first step after cleansing my face in both my morning and nighttime routines. At the 4 week mark I started to notice my fine lines looked waaay more prominent and my skin looked so dull. I knew it had to be the copper peptides because that's the only active I had used in the last 10 months. Before that I was on a course of accutane (so you can only use moisturizer) and I had finished 2 months prior to starting the peptides, period during which I again only used moisturizer. I googled it and I found there's something people are calling the "copper ugglies". It is from using too much copper peptides. Apparently you should only use it 2 or 3 times per week... I was clearly over doing it. I stopped it a week ago and went...
AM
Negative
11/19/2025
I started every 4 days then 3 then 2 and now I use them nightly (1%) without issues.
This particular product I am not a big fan of. The texture is gross and my face is red and burning when I apply it.
ID
Positive
4/28/2025
Are you talking about the copper ugly? Because copper peptide is great for firming the skin. Just use less. I use it 3x a week along with red light therapy (20 mins), love it.
VA
Negative
4/11/2026
I used it topically as a “skin remodeling” agent. After 4-5 months I developed a sensitivity to it and stopped using it. In retrospect I didn’t need any skin remodeling in the first place.
CR
Positive
9/7/2025
I only use GHK-CU (the copper peptide) subcutaneously. I have cycled on and off with another peptide called BPC-157 for a couple of years now. My skin heals faster, it seems thicker yet softer, and it is definitely more resilient. I don't use copper peptides topically because it doesn't play well on my skin with Tretinoin. I am also a fan of red light therapy. Have a mask and panel. Also drink collagen peptide powder. As long as you are consistent with applying peptides 2x's a day, you will see results. I use Snap-8 and other peptides topically. Snap is the secret weapon, however, and lasts about 12 hours. Some others that come to mind in my products are hexapeptide-12, Matrixyl 3000, and Arginine polypeptide. Those I've been using on and off for years; but consistently for the last 2, I think. Maybe 3. For reference: I will be 49...
EY
Negative
11/30/2025
Yeah, this product irritated me so I had to discontinue it. I had to accept the fact that copper peptides and me don’t get along well lol. My skin also can’t tolerate vitamin C, I wonder if there’s a link. But yeah, I would discontinue this if you’re getting a reaction from it.
EM
Mixed
12/3/2025
Late to the party here. I use TO copper peptides BUT I had used it, got a fright and never used it again for a year.
I noticed a somewhat saggy effect, worsening texture, lines appeared more prominent. I went in with it twice a day at first.
It's back in my routine now but I dont use it twice a day, or every day. I use it once every second day and I actually love it now. Maybe before it was just too much copper in one go which I believe can have a paradoxical effect?
I got the same with retinol, however I have never been brave enough to touch that again 😂😂
SP
Negative
1/22/2026
Just noticed smile lines going from my nose to outer corners of my mouth after using this for a week… I never had those lines before EVER! Was using twice a day and will discontinue now… really hope it goes back to normal - makes me look way older and my skin way looser. So frustrating!
JE
Positive
12/9/2025
I use injectable GHK-CU (GLOW is the combo I technically use) and it’s been incredible for hair growth. I’m on tirzepatide for inflammation, and that can cause significant hair loss, so I’m using GLOW to combat that. Within 2 weeks of daily proper use, I had visible new hair growth. I will say, if this is a road you opt to go down, do your homework on the peptide subreddits to determine how to make the injections as painless as possible. They’re SPICY.
LE
Positive
4/12/2026
I did 9 weeks of KLOW first, where the ghkcu was 2-2.5mg nightly. Then I took a week break and started ghkcu on its own. I did 5 weeks of 3.33mg nightly.
The picture shows the before and after for the KLOW protocol. The biggest improvements were reduction in redness, way thicker skin (especially around the eyes), and overall skin softness and smoothness. My hair also improved in that it is no longer oily. I’m hoping with continued use, I’ll see more hair benefits.
I took a 3 week break after the 5 weeks and now am just dosing 2mg a night so the vials last longer. I’m loving the results and will continue to incorporate ghkcu in my routine.
https://preview.redd.it/gtwmlsuqrnug1.jpeg?width=2048&format=pjpg&auto=webp&s=ac2ca8d21c01285adb4d11806d12a1705f4b34d6
NA
Positive
4/11/2026
I’ve been on it for 3 months. I started seeing results (more plump, smooth, less red, and tighter skin) after about a month and I really feel it’s getting better by the day. My face used to get dry and red easily and now I don’t use as much moisturizer and redness completely gone. My hands got really dry and now they’re baby soft it’s insane. And just firmer skin overall specifically on thighs.
I use it daily 2mg (needle fatigue is real keep that in mind) (a 50mg vial with 3ml bac water added which is 12 units a day) sometimes the injection can sting but nothing too bad at least for me. It helps to warm it up in hands before hand for like 30sec
I plan to take a month break after 6 months.
BR
Positive
4/11/2026
I’m about 6 weeks into GHKCU. I take 2mg day. It was a month before I noticed anything and it was slight. Now I’m starting to see much more noticeable improvement. I’m 49 and my skin is looking younger and better. It’s not a miracle…. But it’s a noticeable difference.
EM
Positive
4/12/2026
I have psoriasis flares in some spots and since I started GHK, it has not made a return at all. Weird but a good thing.
AG
Positive
4/12/2026
Used it for 12 weeks , had acne scars , 1/4 of them gone, overall felt good, felt less inflamed and more clear minded (only little side effect ) - bit of diarrhea and pain while injecting
UN
Positive
4/12/2026
I’ve been using 2mg 5 night a week for about 3 months now. Along with micro needling and good skincare, my skin has never looked better. I’m 42 and most people think I’m much younger. No Botox or filler and not a wrinkle in sight! And I rarely need any makeup which is a bonus. Redness has gone down and skin tone and clarity have improved.
My hair hasn’t changed much but I don’t think I’ve been on it long enough to notice that. So far I am happy with it and will continue as I’ve heard using it 8-9 months is what the real changes happen.
WH
Positive
4/12/2026
i love it. since being on it i noticed the bumps and white heads around my hairline have disappeared :) running it for 8 weeks and then taking two weeks off and starting back up again after that
SH
Positive
4/11/2026
Took me about 2 months to start noticing stuff. Was taking 2mg daily. My hair is completely different, its nice thick and soft now. My skin was already flawless so didnt notice anything their, but the hair change is what i was hoping for since i used to have thin hair. Went from being thin and frizzy to soft and lush
LA
Negative
4/11/2026
im doing it topical, cant tolerate when injected as it makes me feel out of touch/ reality, brain fog.
CH
Positive
10/4/2024
I have about four weeks experience with the Anela Protocol (topical/subq) and all I can say is DoctordUp should get a Congressional Metal of Honor or something! Follow instructions to avoid the sting. I saw big results the first week (60 yr old, lost c.45#s), and by week three I was canceling my four-figure cosmetic surgeon quarterly appointment. Pro Tip: Take a zinc supplement so you don’t need to worry about too much copper building up in your system. Do as she says, it is SO worth it!
[D
Positive
10/3/2024
3rd degree burn on my forearm from the edge of a very hot cast iron pan. Almost seemed to heal right before my eyes, the huge burn blister immediately responded and became smaller, within one week it was healed and there is no scar now. GHK-CU cream. I now make sure to always keep some on hand. I tried it as I did not have burn cream and remembered how it can help heal and help your skin and I was happily amazed and relieved. N-1 incident but i am a believer in this stuff now.
GU
Negative
12/21/2025
I had to stop using ghkcu because even when following the Anela protocol I had massive welts that would bruise and cause the entire limb to ache, I wish I could’ve continued but the pain was so bad I couldn’t sleep
CI
Positive
12/2/2024
I started ghk-cu sub q injections and it's getting red and painful sometimes, thanks for the advice I'll try massaging the site after! Other than that I've been using red and near infrared LED lights along with copper peptides topically and methylene blue and getting fantastic results on my skin. I'm 50 and the lines on my face are gone now. I did epithalion as well, excited to see what ghk-cu does for me!
EV
Negative
10/4/2024
I started the ghkcu injection and it burns like crazy so i stopped. Maybe do the glow?? I use the topical .
NE
Negative
1/20/2025
For anyone interested, I injected Ghk cu in my thigh last night, trying to give my stomach a break, and still in pain 20 hours later. I inject with BPC 157, and it always hurts a little afterwards, but NOTHING like this. Everyone is different, but wanted to put this out there in case someone else had this experience, or knows why this would happen
TA
Positive
3/11/2026
i personally really like it. normally i get horribly dry skin in the winter, but run it for about 6 weeks this winter and my skin has been great
[https://peptidewiki.co/guides/dosage-guides/ghk-cu-dosage-guide](https://peptidewiki.co/guides/dosage-guides/ghk-cu-dosage-guide) has a good guide
CH
Positive
4/6/2026
I currently am beginning GHK-Cu at 1mg subq injection. So far I’ve only noticed my hair is growing a bit faster. I can tell by looking at my roots. That’s the only difference I’ve noticed so far. I’ve only been on it around a week.
GU
Negative
12/21/2025
I had to stop using ghkcu because even when following the Anela protocol I had massive welts that would bruise and cause the entire limb to ache, I wish I could’ve continued but the pain was so bad I couldn’t sleep
WI
Mixed
12/22/2025
I’ve been “fighting” this the last 2 weeks (week 3-4 on GHK). Larger, nickel size, itchy welts on my neckline and small rashes on my forearms that come and go. I recently changed soaps/shampoo and started Finasteride (1 month in) so trying to pin point the reaction reason. I also thought Tesa was the culprit but I was halfway through the cycle and stopped to see if IT was the reason. I’m mixing GHK w/BPC daily and Reta weekly but it seems GHK is the real reason. I may take a break from the GHK and finish the Tesa since it was working well.
KN
Positive
12/24/2025
Had the itchiness and hives my first time. Took antihistamine. Was fine day and half latet. Havent had those issues since to the point i dont have to take antihistamines with GHK-CU now
MR
Negative
12/26/2025
Side effects of ghk-cu
So i have been using ghk-cu for 2 weeks now. Today was the first time I used a syringe for a second time and now I have a bruise on the injection site. When I put my finger on it it’s hard and hurts a little. Normal ?
ER
Positive
12/22/2025
I let my GHK CU out of the fridge for 20 minutes prior to pin. It has reduced the sting to zero
WI
Mixed
12/22/2025
I’ve been “fighting” this the last 2 weeks (week 3-4 on GHK). Larger, nickel size, itchy welts on my neckline and small rashes on my forearms that come and go. I recently changed soaps/shampoo and started Finasteride (1 month in) so trying to pin point the reaction reason. I also thought Tesa was the culprit but I was halfway through the cycle and stopped to see if IT was the reason. I’m mixing GHK w/BPC daily and Reta weekly but it seems GHK is the real reason. I may take a break from the GHK and finish the Tesa since it was working well.
DA
Mixed
12/22/2025
I am doing 1mg a day reconstituded 2.5mg of bac water and pin 5units daily. I got the itching the first dose I took and rash everywhere 3 hours prior. Haven't had the experience since.
KN
Positive
12/24/2025
Had the itchiness and hives my first time. Took antihistamine. Was fine day and half latet. Havent had those issues since to the point i dont have to take antihistamines with GHK-CU now
BE
Positive
11/6/2025
AFTER my first cycle, I noticed my hair coming in fuller than it has in years! Others also noticed my fuller hair.
IT
Positive
1/27/2026
I started using then two months ago 2mg a day amazing results my skin glows n it even reflects light now lol and im having new hair growth around my hairline then my wife saw the changes she has hyperpigmentation dark circles and few other issues shes been using it to for around 4 weeks now its 2mg aswell her hyperpigmentation is gone on left side and right side about 85 percent gone dark circles gone aswell skin is more clear and my skin is like next level but my diet is really clean aswell i complete all vitamins minerals everyday drink 3-4 liters of water take ZMA vitamin e c vitamin D and vitamin B and i have a full weekly skincare routine with copper peptide and retinol vitamin c n few other things planned different on each day of the week. I can share my skin care routine...
MA
Positive
11/5/2025
I started using it topically at 4% with hyaluronic acid on my face and bat wings. Ha. 3 weeks of 4x week nightly use, alternating with trentoin- has done WAY more than injecting ghk-cu. But if you’ve got it in a blend, more power to you!
Also, subq helps disburse it throughout the body. So I can’t yuck anyone’s yums here.
MA
Positive
11/6/2025
6 weeks in
Rs takes 2mg daily
Fuller skin plumper tougher. Not a miles difference but starting to notice injections need abit more umph to pierce skin. Weird side not but yeah.
As far as anything else physical havent really been much of a change.
LO
Positive
4/10/2026
I’ve been on 5mg daily for four months now, with one three week break in between. I started at 1.5, then moved to 2 based on Anela. At 2 I was noticing some effect but not enough. Went to four, then eventually 5. Take a zinc supplement. Skin is beautiful, soft and glowing. Even my stretch marks are GONE!
MO
Mixed
4/9/2026
Podcaster Tara West just released an episode where she did just this. She said she "accidentally" took double the dose (from 2.5 to 5.0) and noticed a more pronounced response in her skin. She said this also caused her to experience eating diversion. She said she just wasn't hungry. While she explained this is not the intended response, this was a side effect to the higher dosage.
She's a seemingly well-informed user of peptides which makes me question the accidental double dose.
MR
Positive
3/16/2026
Takes about 6 weeks to start seeing improvements for many. I started noticing fine lines in my forehead were going away and my turkey neck from weight loss of over 190LBS is going away as well. Stuff works like magic! I've been on it for 4 month's now and people tell me I loook 5 years younger already. My hair and nails are growing really fast as well.
DU
Positive
3/14/2026
Im 5 weeks in and my scalp eczema has gone completely and for the first time in years i have nothing anywhere else either - feel pretty annoyed that i didnt know about this earlier as have spent years having docs throw topical steroids at me im 51f 🙏🙏 i will be forever grateful for finding myself down the peptide rabbit hole 😍
SE
Positive
3/14/2026
I've been on and off it for quite some time. Problem is I take other peptides that have either a direct impact on your skin. I use or have used these in conjunction with GHK-Cu: BPC-157 → healing and repair KPV → anti-inflammatory skin support Epitalon → longevity / anti-aging signaling TB-500 → deeper tissue repair Obviously, three of these are commonly found in the KLOW blend. That said, GHK-Cu has been shown in gene expression research to activate or suppress over 4,000 human genes, many related to skin regeneration and collagen synthesis. That’s one reason it’s considered one of the most powerful peptides for skin quality. In my personal experience, GHK-Cu has had a pretty noticeable impact on my hair and skin quality. Obviously everyone is different, but it’s one of the compounds where I’ve actually seen visible changes. This definitely has not happened overnight. There is also NAD⁺...
RE
Positive
3/14/2026
From my reading and research this is what i understand. You shouldnt expect to start to see improvements (in regards to skin texture/ageing etc) until around week 6 and even then it will most likely be minimal. Its weeks 6-12 that things should really start to kick in to gear. And then realistically you probably want a good 6 months on it to see the full results. Im on about week 5. I am suspecting that i am getting the “copper uglies” on my neck as it looks super crepey its weird, never been like that before. But apparently its the collagen remodeling. That being said, i have always had thin, brittle, weak nails that take long time to grow. Well from about week 2 my nails have been strong and healthy and now at week 5 they are the longest, strongest, thickest they have ever been. But apparently the...
DA
Positive
3/14/2026
I’ve use GHKU-cu SubQ for the past 8 days now.
I saw result within the first 1-2 days on my skin quality and some old scars started healing. Seeing progress on this every single day. Even my partner for 15 years clearly sees the difference
TR
Positive
3/14/2026
6 weeks in... What i have noticed is better skin, cant explain but my hair feels fuller and silkier "lol" i ve heard you can use it year round but not sure will go by how i feel.
TE
Positive
3/14/2026
I’m a month in and noticing decreases in wrinkles. Not giant but noticeable differences. Also, I have had chronic cracked heels for literally decades. I have definitely noticed a decrease there in the severity and depth of the cracking. This is not why I was taking it but happy with that for sure.
SL
Positive
3/14/2026
One month on ghkcu and my lab rat has much smoother thicker skin, seems a little tighter and a black spot on his lip is gone. 2nd month added kpv for 2nd month and all acne is gone
RU
Mixed
3/14/2026
I have used it for two 8 week cycles but I think the 1-2 mg dose might have been to much. At the end of the last one I had consistent small blemishes in random places. Next one I’m might try .5
I’m not sure how much difference I notice in general though.
EL
Positive
3/14/2026
After 4 weeks my sagging skin from weight loss is noticeably better. Have noticed the crepey skin on my arms and neck are marginally better. 2-2.5 mg subQ per day and topically in areas as I remember or have time for (habitually late to things so sometimes it doesn’t happen)
PO
Positive
3/14/2026
5 weeks in and starting to see a difference.
Can tell it's working since my nails are growing much faster than usual. Skin feels tighter as well. Going to run it for 16 weeks.
CE
Positive
3/14/2026
Took a solid 5 months before noticing anything.
And I was dosing 3mg
Skin improvement. Yes
Hair no
NA
Positive
3/14/2026
I've pinned it for 3 months everyday. Results are great. Even pinning my skin is definitely harder. Hair is definitely thicker. I'm preparing to cycle off pinning and making my own serum with GHK and Snap for about a month. Then I'll cycle back on pinning.
TY
Positive
3/14/2026
I never got the “skin purge” that people talk about - acne and worse skin before it cleans up - but the healthy looking face came in at about week 3, crows feet kind of filled in, reducing fine wrinkles. I am at 8 weeks now
JE
Positive
3/17/2026
5 weeks in on GHK-CU and my bald spot started to fill in, my hair got darker, and skin was looking better. It depends on the person.
LU
Positive
10/15/2025
You can start low. I see no problem.
I started with 0,5mg and went up to about 1mg per day. Thats my sweet spot.
I feel it working on my skin and I have no side effects like on higher doses.
There is no must, that you use 2 mg or more per day. everyone is different.
RO
Positive
2/11/2026
I started low as I do with any peptide to see how my body reacts. I dose 1.5mg every other day now, I’ve only been on it a month and my face is absolutely looking more plumper and clear. I’ll stay on it until my vile runs out. Prob 2,3 months then take a break and cycle back on.
JO
Mixed
2/12/2026
I’ve been taking it for a month now. My first dose made my heart rate spike and I got pretty nauseous. I do a KLOW blend and I find that it helps if I eat before I pin it.
GL
Positive
2/14/2026
Great peptide. Been doing for about a year. Labs all good. Great for skin and hair and just generally looking and feeling young. I take breaks - but def recommend. Listen to your body and adjust if needed.
HU
Negative
8/11/2025
2 mg 2 times a week gave me the worst headaches and nausea, start low and build up
TR
Positive
8/4/2025
I’ve completed one cycle and half way through the second.
I buy 50mg vials also. Since this peptide can cause a histamine reaction around the injection site, which can be slightly painful for a day or two, I try to make it as dilute as possible. So, I reconstitute with 3mL of BAC water. That gives me a concentration of 16.667mg/mL. At that concentration, every 10 units (0.1mL) delivers 1.667mg. 12 units = 2.0mg.
I take 2mg/day, 7 days a week, for 6 weeks. Then I take a 2-3 week break. Rinse, repeat. During the 6 weeks on, I also take a 25mg zinc supplement. I’ve noticed a substantial improvement in skin quality. It’s thicker and smoother. I was hoping that it would help with my thinning hair, but I haven’t noticed much change there.
10mg/day sounds *way* too much.
DO
Positive
2/23/2026
I’ve noticed my white hairs reverting to black on my head and face. Also within a couple weeks, my skin looks smoother and feels tighter. Head hair regrowth has also happened to a high degree. I use a few other interventions though so hard to attribute that to the ghk.
MU
Positive
2/22/2026
Have heard about the “copper purge”, but first let me ask if you are 100% certain you got high quality GHK-CU. I’ve taken it for 2 weeks and just in the last 1-2 days noticing the skin smoothening - visibly looking in mirror and feeling my face. Also when pinning, the skin being tougher to penetrate with needle - started seeing this within the first 3-4 days.
NO
Positive
2/22/2026
im on Accutane and ghk-cu and one things for sure sure it 10000% helps heal scars faster and pimples its amazing
GO
Positive
2/23/2026
I've been pinning 5mg daily of only ghk-cu for about a month now, and I've definitely seen improvements. I'm a 54 yo male, btw. Hair is filling back in. Crepey skin is looking tighter and smoother. My only complaint is the increased facial acne. From my research, that will go away eventually. I'm quite pleased with my results. I have ten 100mg vials, so I'm stocked up for the long haul. No plans to cycle off of this one.
LA
Mixed
2/22/2026
i tried it few times pinning but it gives me brain fog, but i will re-challenge again next week. meanwhile it's been 1 month on topical already, it somehow grows tiny teeny vellus hairs but never goes longer than a centimeter lol
MK
Positive
2/23/2026
Purging not quite I been feeling greate skin is more plum more younger in away I’d say cuz of elasticity of skin and less fine line on my forehead still there but tiny bit less than before I noticed but otherwise no purging no ugly copper
LI
Positive
2/24/2026
My hair is growing so much!! I’ve got all these baby hairs that I thought were frizz but nope it’s new hair growth. I started taking this for my skin, and was SHOCKED when it also started healing my gut!! I also stopped the Botox. This is a miracle peptide I’m gonna get my mom on it.
ON
Positive
2/26/2026
I've been on it for about 4 months at 2mg/day.
I did hit a point where I started losing my hair - the pattern did not follow MPB and this did cause me some stress, but I realized it was causing a new growth phase. hair is filling out and is growing well. Skin looks amazing. I've been running the KLOW stack - as I had surgery and was using the combo to help with recovery and scarring - along with the other benefits. I'll be switching to just GHK-Cu once my latest bottle of KLOW is complete
AU
Positive
2/26/2026
About 4 weeks. My hair has improved. A little softer compared to w/o ghkcu. Less flakes on my scalp too.
For the skin, bumps on my face started to become smaller. Sometimes I would run my nails on the bumps and whitehead will come out pretty quick. Like, as if they were just out there hanging waiting to be wiped off. Pimple dries fast.
I haven't noticed about the white hair because mine was dyed before I got on to this wonderful peptide.
MR
Negative
12/26/2025
Side effects of ghk-cu
So i have been using ghk-cu for 2 weeks now. Today was the first time I used a syringe for a second time and now I have a bruise on the injection site. When I put my finger on it it’s hard and hurts a little. Normal ?
DU
Positive
3/14/2026
Im 5 weeks in and my scalp eczema has gone completely and for the first time in years i have nothing anywhere else either - feel pretty annoyed that i didnt know about this earlier as have spent years having docs throw topical steroids at me im 51f 🙏🙏 i will be forever grateful for finding myself down the peptide rabbit hole 😍
SE
Positive
3/14/2026
I've been on and off it for quite some time. Problem is I take other peptides that have either a direct impact on your skin. I use or have used these in conjunction with GHK-Cu: BPC-157 → healing and repair KPV → anti-inflammatory skin support Epitalon → longevity / anti-aging signaling TB-500 → deeper tissue repair Obviously, three of these are commonly found in the KLOW blend. That said, GHK-Cu has been shown in gene expression research to activate or suppress over 4,000 human genes, many related to skin regeneration and collagen synthesis. That’s one reason it’s considered one of the most powerful peptides for skin quality. In my personal experience, GHK-Cu has had a pretty noticeable impact on my hair and skin quality. Obviously everyone is different, but it’s one of the compounds where I’ve actually seen visible changes. This definitely has not happened overnight. There is also NAD⁺...
RE
Positive
3/14/2026
From my reading and research this is what i understand. You shouldnt expect to start to see improvements (in regards to skin texture/ageing etc) until around week 6 and even then it will most likely be minimal. Its weeks 6-12 that things should really start to kick in to gear. And then realistically you probably want a good 6 months on it to see the full results. Im on about week 5. I am suspecting that i am getting the “copper uglies” on my neck as it looks super crepey its weird, never been like that before. But apparently its the collagen remodeling. That being said, i have always had thin, brittle, weak nails that take long time to grow. Well from about week 2 my nails have been strong and healthy and now at week 5 they are the longest, strongest, thickest they have ever been. But apparently the...
DA
Positive
3/14/2026
I’ve use GHKU-cu SubQ for the past 8 days now.
I saw result within the first 1-2 days on my skin quality and some old scars started healing. Seeing progress on this every single day. Even my partner for 15 years clearly sees the difference
TR
Positive
3/14/2026
6 weeks in... What i have noticed is better skin, cant explain but my hair feels fuller and silkier "lol" i ve heard you can use it year round but not sure will go by how i feel.
TE
Positive
3/14/2026
I’m a month in and noticing decreases in wrinkles. Not giant but noticeable differences. Also, I have had chronic cracked heels for literally decades. I have definitely noticed a decrease there in the severity and depth of the cracking. This is not why I was taking it but happy with that for sure.
SL
Positive
3/14/2026
One month on ghkcu and my lab rat has much smoother thicker skin, seems a little tighter and a black spot on his lip is gone. 2nd month added kpv for 2nd month and all acne is gone
RU
Negative
3/14/2026
I have used it for two 8 week cycles but I think the 1-2 mg dose might have been to much. At the end of the last one I had consistent small blemishes in random places. Next one I’m might try .5
I’m not sure how much difference I notice in general though.
EL
Positive
3/14/2026
After 4 weeks my sagging skin from weight loss is noticeably better. Have noticed the crepey skin on my arms and neck are marginally better. 2-2.5 mg subQ per day and topically in areas as I remember or have time for (habitually late to things so sometimes it doesn’t happen)
PO
Positive
3/14/2026
5 weeks in and starting to see a difference.
Can tell it's working since my nails are growing much faster than usual. Skin feels tighter as well. Going to run it for 16 weeks.
CE
Negative
3/14/2026
Took a solid 5 months before noticing anything.
And I was dosing 3mg
Skin improvement. Yes
Hair no
NA
Positive
3/14/2026
I've pinned it for 3 months everyday. Results are great. Even pinning my skin is definitely harder. Hair is definitely thicker. I'm preparing to cycle off pinning and making my own serum with GHK and Snap for about a month. Then I'll cycle back on pinning.
TY
Positive
3/14/2026
I never got the “skin purge” that people talk about - acne and worse skin before it cleans up - but the healthy looking face came in at about week 3, crows feet kind of filled in, reducing fine wrinkles. I am at 8 weeks now
JE
Positive
3/17/2026
5 weeks in on GHK-CU and my bald spot started to fill in, my hair got darker, and skin was looking better. It depends on the person.
GU
Negative
12/21/2025
I had to stop using ghkcu because even when following the Anela protocol I had massive welts that would bruise and cause the entire limb to ache, I wish I could’ve continued but the pain was so bad I couldn’t sleep
ER
Positive
12/22/2025
I let my GHK CU out of the fridge for 20 minutes prior to pin. It has reduced the sting to zero
Effects Overview
Side effects and benefits reported by users
Skin Improvement
The Skin Improvement category encompasses a range of benefits reported by users regarding the enhancement of skin appearance and health. Users frequently mention improvements such as reduced redness, smoother texture, and a more youthful glow. Common items include smoother skin, reduced fine lines, and overall healthier looking skin. Many users also report significant changes in skin hydration and elasticity, leading to a more radiant complexion.
Examples: reduction in redness, smoother skin, glowy skin, reduced fine wrinkles, healthier looking skin
33%
reported
Hair Improvement
The Hair Improvement category highlights the benefits users experience related to hair health and growth. Many users report faster hair growth, increased thickness, and overall improved hair condition. Key examples include new hair growth and reduced hair thinning, which contribute to a fuller appearance. Users also mention benefits such as stronger nails and improved scalp health, indicating a holistic effect on hair and surrounding tissues.
Examples: faster hair growth, thicker hair, new hair growth, improved hair fullness, hair regrowth
8%
reported
Overall Satisfaction
The Overall Satisfaction category reflects users' general contentment with the product and its results. Users frequently report great results and a boost in self-confidence after using the medication. Common sentiments include appreciation for long-term benefits and noticeable improvements in skin and hair quality. Many users also highlight the absence of side effects, contributing to a positive overall experience.
Examples: great results, good results for the first month, long-term benefits, self-confidence boost, love for product
5%
reported
Healing and Recovery
The Healing and Recovery category encompasses benefits related to the healing of skin and other injuries. Users often report faster healing times for breakouts and skin injuries, along with a reduction in inflammation. Common examples include effective healing of skin irritations and quicker recovery from conditions like psoriasis and hives. Many users also mention the absence of scarring, indicating a positive impact on overall skin recovery.
Examples: healing, faster healing of breakouts, effective for healing
3%
reported
Hair Growth
The Hair Growth category highlights the specific benefits related to the acceleration of hair growth and overall hair health. Users frequently report faster hair growth and thicker hair, with many noting improvements in hair quality and strength. Common examples include filled bald spots and new hair growth, indicating effective regrowth. Additionally, users mention benefits extending to nail growth, showcasing a broader impact on hair and nail health.
Examples: faster hair growth, new hair growth, hair regrowth
3%
reported
Skin Hydration
The Skin Hydration category focuses on the benefits users experience in terms of skin moisture and hydration. Many users report that their skin feels more hydrated and plump, with softer lines and improved resilience. Key examples include enhanced hydration and a bouncier appearance, which contribute to a healthier look. Users also mention calming effects on the skin, helping to reduce redness and irritation.
Examples: hydrated skin, moisturizing, keeps skin hydrated
3%
reported
Skin Tightening and Firming
The Skin Tightening and Firming category highlights the benefits users experience in terms of skin elasticity and firmness. Many users report noticeable lifting and tightening effects, contributing to a more youthful appearance. Common examples include improved firmness and reduced sagging, which enhance overall skin texture. Users appreciate the visible reduction of fine lines and the perky look achieved through regular use.
Examples: lifting, tightening skin, firming skin
2%
reported
Pain Relief
The Pain Relief category encompasses benefits related to the alleviation of discomfort and pain. Users often report significant pain relief and a reduction in discomfort over time. Key examples include effective pain management techniques and the absence of pain during use. Many users also mention reduced sting and overall satisfaction with the pain relief provided by the product.
Examples: pain relief, less pain, no pain
2%
reported
Scarring
The Scarring category focuses on the benefits related to the healing and improvement of scars. Users frequently report healing of scars and significant improvements in the appearance of acne scars. Key examples include smoothing of surgical scars and fading of pimple scars, indicating effective scar treatment. Many users also mention the absence of new scarring, showcasing the product's positive impact on skin recovery.
Examples: healed scars, helped with acne scars, smoothing of surgical scar
2%
reported
General Benefits
The General Benefits category encompasses a variety of positive effects reported by users that do not fit into specific categories. Users often highlight the absence of side effects and the safety of the peptide. Common examples include easier administration and anti-inflammatory benefits, which contribute to overall satisfaction. Many users appreciate the thorough testing and monitoring of results, reinforcing confidence in the product's efficacy.
Examples: no side effects, safer peptide, third-party testing
2%
reported
Wound Healing
The Wound Healing category focuses on the benefits related to the accelerated healing of wounds and skin injuries. Users frequently report faster healing times and improved scar appearance. Key examples include smoothing of scars and effective healing of cystic pimples, indicating the product's efficacy in wound recovery. Many users also mention healing of internal issues, such as gut health, showcasing a broader impact on recovery.
Examples: sped up healing of wounds, heals scars faster
1%
reported
Eczema and Acne Treatment
The Eczema and Acne Treatment category highlights the benefits users experience in managing skin conditions like eczema and acne. Users often report significant improvements in acne and faster drying of pimples. Common examples include clearing of scalp eczema and effective treatment of cystic pimples, indicating the product's efficacy in addressing these issues. Many users appreciate the visible improvements in skin clarity and overall condition.
Examples: cleared scalp eczema, reduced acne, cleared cystic pimples
1%
reported
Gut Health
The Gut Health category focuses on the benefits related to digestive health and overall gut function. Users frequently report improvements in gut health and healing, with some noting better A1C levels. Common examples include enhanced digestive function and overall well-being, indicating a positive impact on health. Many users appreciate the holistic benefits that extend beyond skin and hair.
Examples: improved gut health, gut healing
1%
reported
Weight Management
The Weight Management category highlights the benefits related to weight control and metabolic health. Users often report weight loss as a significant benefit, with some noting improvements in A1C levels. This category reflects the product's potential impact on overall health and weight management, contributing to a more balanced lifestyle.
Examples: weight loss, improved A1C levels
0%
reported